转化医学杂志2024，Vol.13Issue(11)：2039-2042,4.DOI:10.3639/j.issn.2095-3097.2024.11.054
呋塞米早期给药与急性心力衰竭患者氧合改善的关系
The Relationship between Early Administration of Furosemide and Oxygenation Improvement in Patients with Acute Heart Failure
摘要
Abstract
Objective To explore the relationship between early administration of furosemide(F)and oxygenation im-provement in patients with acute heart failure(AHF).Methods This study screened 200 AHF patients who received intra-venous F treatment within 24 hours after arriving at the hospital from April 2023 to April 2024.They were divided into an early administration group(F time≤60 min)and a non-early administration group(F time>60 min).The oxygenation rate of the two groups and the correlation between administration time and in-hospital mortality were compared.Results The early admin-istration group was more likely to arrive by ambulance(P<0.000 1),had higher systolic and diastolic blood pressures(P<0.000 1),and had a higher heart rate/heartbeat(P<0.001).There was no significant difference in New York Heart Association Functional Classification(NYHA)between the early administration group and the non-early administration group(P>0.05).The Get With The Guidelines-Heart Failure(GWTG-HF)score of the early administration group was lower than that of the non-early group(P<0.05).After the diagnosis of AHF,compared with the non-early treatment group,there was no significant difference in ox-ygen saturation of patients before F administration in the early administration group(P>0.05).After F administration,there was a significant difference in oxygen saturation of patients(P<0.000 1).The oxygen saturation of patients increased significantly within 24 hours after treatment(P<0.000 1).During hospitalization,compared with the non-early treatment group,the in-hospi-tal mortality rate of the early treatment group was significantly reduced(P<0.01).Conclusion Early administration of F has a significant positive impact on the oxygenation rate and in-hospital mortality of patients with AHF.关键词
呋塞米/急性心力衰竭/氧合/作用机制Key words
Furosemide/Acute Heart Failure/Oxygenation/Mechanism of Action分类
医药卫生引用本文复制引用
姚飞,杨柳,孟锐,王丹妮..呋塞米早期给药与急性心力衰竭患者氧合改善的关系[J].转化医学杂志,2024,13(11):2039-2042,4.基金项目
航天医疗健康科技集团有限公司科研项目(2023YK18) （2023YK18）
