浙江大学学报（医学版）2025，Vol.54Issue(1)：21-27,中插17-中插19,10.DOI:10.3724/zdxbyxb-2024-0610
全球钙化性主动脉瓣疾病负担的性别和年龄别差异研究
Sex and age distribution of global disease burden of calcific aortic valve disease
摘要
Abstract
Objective:To analyze sex and age distribution of global disease burden of calcific aortic valve disease(CAVD)from 1990 to 2021.Methods:CAVD data during 1990-2021 were obtained from the IHME website for Global Burden of Disease(GBD).The prevalence,mortality,years lived with disability(YLDs),and disability-adjusted life years(DALYs)were analyzed by gender and age groups.Joinpoint regression was used to calculate annual percentage change(APC)and average annual percentage change(AAPC).Results:In 2021,there were 13.32 million CAVD patients and 142 000 deaths caused by CAVD globally.Age-standardized prevalence was higher in males(193.2/105)than that in females(128.9/105).Patients in 65-<85 age group accounted for 64.0%of total cases,while those≥85 years old accounted for 16.1%.From 1990 to 2021,prevalence increased in both sexes with an AAPC of 0.72%for males and 0.57%for females,respectively.Prevalence grew fastest from 2000 to 2010,slowed thereafter,and declined from 2015 to 2021.In<65 years old,the mortality of males was 2.4 times higher than that of females,while in≥85 years old,mortality of females(117.3/105)exceeded that of males(99.1/105).YLD rates increased with age,and were higher in males for all age groups.DALY rates decreased overall but increased in≥85 years old,with a greater increase in females.Conclusions:There are significant gender and age disparities in global disease burden of CAVD,with the elderly,especially super-elderly females deserving particular attention.It is recommended to develop personalized intervention strategies for these populations.关键词
钙化性主动脉瓣疾病/全球疾病负担/性别差异/年龄别差异Key words
Calcific aortic valve disease/Global burden of disease/Gender differences/Age-specific differences分类
医药卫生引用本文复制引用
邓湘宁,隋鑫宇,李楠,冯杰莉,陈少敏,徐昕晔,唐熠达,汪宇鹏..全球钙化性主动脉瓣疾病负担的性别和年龄别差异研究[J].浙江大学学报（医学版）,2025,54(1):21-27,中插17-中插19,10.基金项目
国家重点研发计划(2023YFC2414403) This work was supported by the National Key R&D Program of China(2023YFC2414403) （2023YFC2414403）
