浙江大学学报（医学版）2025，Vol.54Issue(1)：70-80,11.DOI:10.3724/zdxbyxb-2024-0213
病毒感染诱导细胞衰老的机制及意义
Mechanism and significance of cell senescence induced by viral infection
摘要
Abstract
Virus-induced senescence(VIS)is a significant biological phenomenon,which is associated with declining immune function,accelerating aging process and causing aging-related diseases.A variety of common viruses,including RNA viruses(such as SARS-CoV-2),DNA viruses(such as herpesviruses and hepatitis B virus),and prions can cause VIS in host cells.The primary mechanisms include abnormal activation of the cGAS-STING signaling pathway,DNA damage response,and potential correlations with the integrated stress response due to intracellular phase separation.Viral infection and cellular senescence influence each other:cellular senescence serves as a defense to restrict viral replication and transmission,while some viruses exploit cellular senescence to enhance their infectivity and replication.Understanding the mechanisms of VIS is conducive to the development of therapeutic strategies for viral infections and promotion of healthy aging.However,there is lack of research on therapeutic targets and drug development in this field so far.Although senolytics may be effective for anti-senescent cells therapy,their efficacy for VIS needs evidence from further clinical trials.This article reviews the research progress on the connection between viral infection and cellular senescence,to provide insights for the prevention and treatment of aging related diseases.关键词
细胞衰老/病毒感染/环鸟苷酸-腺苷酸合成酶-干扰素基因刺激因子/DNA损伤应答/综述Key words
Cell senescence/Viral infection/cGAS-STING/DNA damage response/Review分类
医药卫生引用本文复制引用
常允闯,吴辛娜,邓伶俐,王三应,毛根祥..病毒感染诱导细胞衰老的机制及意义[J].浙江大学学报（医学版）,2025,54(1):70-80,11.基金项目
国家中医药管理局科技司-浙江省共建项目(GZY-ZJ-KJ-24055,GZY-KJS-ZJ-2025-074) （GZY-ZJ-KJ-24055,GZY-KJS-ZJ-2025-074）
国家重点研发计划(2022YFC3501802) （2022YFC3501802）
浙江省医药卫生科技计划(2022KY009) This work was supported by the Science and Technology Department of the National Admin-istration of Traditional Chinese Medicine and the Zhejiang Proincial Joint Construction Project(GZY-ZJ-KJ-24055,GZY-KJS-ZJ-2025-074),National Key R&D Program of China(2022YFC3501802),Zhejiang Provincial Medical and Health Science and Technology Plan(2022KY009) （2022KY009）
