浙江大学学报（医学版）2025，Vol.54Issue(1)：81-89,9.DOI:10.3724/zdxbyxb-2024-0208
金属卟啉对抗神经退行性变性疾病的研究进展
Research progress of metalloporphyrin against neurodegene-rative diseases
摘要
Abstract
Neurodegenerative diseases are a group of diseases caused by the degeneration and apoptosis of neurons in the brain and spinal cord,which seriously affect human ability of motion perception,memory and cognition.Peroxynitrite can cause oxidative damage in the brain by exhibiting neurotoxicity,and its excessive accumulation is closely related to neurodegenerative diseases.Therefore,effectively scavenging peroxynitrite may become a therapeutic strategy for neurodegenerative diseases.Due to their high peroxynitrite scavenging ability,water-soluble metalloporphyrins have recently attracted much attention.Metalloporphyrins such as iron porphyrins and manganese porphyrins have neuroprotective effects,including inhibiting amyloid plaque accumulation,alleviating oxidative stress and neuroinflammatory damage,improving mitochondrial function and reducing neuronal apoptosis.However,some metalloporphyrins have poor blood-brain barrier penetration.To overcome this obstacle,in addition to traditional synthesis processes,metalloporphyrins can also be prepared into nanoparticles to improve bioavailability in vivo.Here,we will review the mechanisms underlying the neuroprotective effects of metalloporphyrins and explore their therapeutic potential for neurodegenerative diseases.关键词
神经退行性变性疾病/过氧亚硝酸盐/金属卟啉/综述Key words
Neurodegenerative diseases/Peroxynitrite/Metallporphyrins/Review分类
医药卫生引用本文复制引用
陈洁,陆静,王庆怡,楚楚,曾玲晖,赵杰..金属卟啉对抗神经退行性变性疾病的研究进展[J].浙江大学学报（医学版）,2025,54(1):81-89,9.基金项目
浙大城市学院科研培育基金(X-202103) （X-202103）
浙江省自然科学基金(LTGD23C050001) This work was supported by the Scientific Research Foundation of Hangzhou City University(X-202103),Natural Science Foundation of Zhejiang Province(LTGD23C050001) （LTGD23C050001）
