浙江大学学报（医学版）2025，Vol.54Issue(1)：90-98,9.DOI:10.3724/zdxbyxb-2024-0249
肝疾病中炎症衰老机制研究进展
Advances in inflammaging in liver disease
摘要
Abstract
Inflammaging is a process of cellular dysfunction associated with chronic inflammation,which plays a significant role in the onset and progression of liver diseases.Research on its mechanisms has become a hotspot.In viral hepatitis,inflammaging primarily involve oxidative stress,cell apoptosis and necrosis,as well as gut microbiota dysbiosis.In non-alcoholic fatty liver disease,inflammaging is more complex,involving insulin resistance,fat deposition,lipid metabolism disorders,gut microbiota dysbiosis,and abnormalities in NAD+metabolism.In liver tumors,inflammaging is characterized by weakening of tumor suppressive mechanisms,remodeling of the liver microenvironment,metabolic reprogramming,and enhanced immune evasion.Therapeutic strategies targeting inflammaging have been developing recently,and antioxidant therapy,metabolic disorder improvement,and immunotherapy are emerging as important interventions for liver diseases.This review focuses on the mechanisms of inflammaging in liver diseases,aiming to provide novel insights for the prevention and treatment of liver diseases.关键词
肝疾病/炎症衰老/作用机制/干预/综述Key words
Liver diseases/Inflammaging/Mechanism/Intervention/Review分类
医药卫生引用本文复制引用
徐燕萍,陈璐祎,刘玮丽,陈丽英..肝疾病中炎症衰老机制研究进展[J].浙江大学学报（医学版）,2025,54(1):90-98,9.基金项目
浙江省医共体建设发展齐鲁研究项目(2024ZHA-QL206) The study was supported by the Zhejiang Province Medical Community Construction and Development Qilu Research Program(2024ZHA-QL206) （2024ZHA-QL206）
