质谱学报2025，Vol.46Issue(2)：224-232,9.DOI:10.7538/zpxb.2024.0120
三种应用场景中聚乙醇酸低聚物的迁移和形成机理研究
Study on Migrants and Formation Mechanism of Polyglycolic Acid Oligomers in Three Distinct Application Scenarios
摘要
Abstract
Poly(glycolic acid)(PGA)is an environmentally friendly,biodegradable polymer commonly utilized in biomedical applications.Due to its high thermal deformation temperature,favorable mechanical properties,and effective gas barrier capabilities,PGA has potential application as food contact materials.However,current regulations do not explicitly involve the use of PGA in food contact applications,particularly the migration of oligomers.The potential migration of oligomers from PGA into food must be carefully considered.In this study,a method of ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UHPLC-QTOF MS)was developed for the determination of PGA oligomers.The migration of oligomers in three distinct scenarios were investigated,i.e.packaging for frozen food,disposable containers with heat packaging for short-term storage,and containers for hot food and beverages.These scenarios were assessed in various food simulants,including acidic foods,non-acidic foods,and alcoholic beverages.The results showed that a total of 21 oligomers in PGA samples are identified,including 12 linear oligomers and 9 cyclic oligomers.Notably,the retention time of these oligomers increases with the increase of number of polymerization units.When PGA was employed as packaging for frozen foods,no oligomers are detected in food simulants containing 4%acetic acid,10%ethanol,or 50%ethanol.In contrast,a variety of linear and cyclic PGA oligomers are identified in the three food simulants when PGA was used for disposable containers with heat packaging and for hot food and beverages.This is particularly evident for linear oligomers GA5 to GA8 and cyclic oligomers GA6 to GA8.The potential mechanisms underlying the migration and formation of these oligomers can be explained that the non-crystalline regions of PGA are an amorphous state,where ester bonds are prone to gradual hydrolysis,facilitated by the diffusion of water molecules.This hydrolysis leads to the cleavage of chain segments,resulting in the generation of long-chain oligomers.Short-chain oligomers,characterized by lower molecular weights,exhibit a higher tendency to migrate into surrounding solutions,particularly within the non-crystalline regions formed by the degradation of long-chain oligomers.Furthermore,short-chain oligomers can undergo self-reorganization from a disordered to an ordered state,facilitating the formation of both linear and cyclic oligomers.Temperature also significantly influences the formation of PGA oligomers,and elevated temperatures lead to a greater variety of oligomers and increased migration concentrations.Therefore,the migration of PGA oligomers into food should be carefully considered in scenarios involving the storage of acidic foods,non-acidic foods,and alcoholic beverages at high temperature.关键词
超高效液相色谱-串联四极杆飞行时间质谱(UHPLC-QTOF MS)/聚乙醇酸/低聚物/迁移量/食品接触材料Key words
ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UHPLC-QTOF MS)/polyglycolic acid/oligomers/migrants/food contact materials分类
化学化工引用本文复制引用
刘胜峰,梁进欣,尹甜,陈胜,段逸品,董犇,李丹,钟怀宁..三种应用场景中聚乙醇酸低聚物的迁移和形成机理研究[J].质谱学报,2025,46(2):224-232,9.基金项目
国家能源集团2030重大项目先导项目(GJNY2030XDXM-19-15.4) （GJNY2030XDXM-19-15.4）
广州海关科研项目(2021GZCK22) （2021GZCK22）
