摘要
Abstract
Objective:To evaluate the clinical efficacy of Low Molecular Weight Heparin combined with Compound Amino Acid and Magnesium Sulfate in pregnant women with fetal growth restriction(FGR).Method:A total of 102 pregnant women with FGR were included from Shishi Maternal and Child Health Hospital from December 2020 to December 2023 were selected as the study subjects.The groups were divided by touch ball method,with odd numbers as control group(n=51)and even numbers as observation group(n=51).The pregnant women in the control group were treated with Compound Amino Acid combined with Magnesium Sulfate,and the pregnant women in the observation group were treated with Low Molecular Weight Heparin on the basis of the control group.Fetal development[femur length,biparietal diameter,abdominal circumference,head circumference],fetal umbilical blood flow indexes[fetal umbilical artery resistance index(RI),pulse index(PI),systolic-to-diastolic velocity ratio(S/D),end diastolic velocity(EDV)],maternal hemorheology[(whole blood high shear viscosity(WBHSV),whole blood low shear viscosity(WBLSV),blood plasma viscosity(BV),hematocrit(HCT)]before treatment and 1 week after treatment were compared between the two groups.Result:After 1 week of treatment,the femur length,biparietal diameter,abdominal circumference and head circumference of the fetus in the two groups increased compared with those before treatment,and the indexes in the observation group were longer than those of the control group,the differences were statistically significant(P<0.05).After 1 week of treatment,the fetal RI,PI and S/D in both groups decreased compared with those before treatment,and the indexes in the observation group were lower than those in the control group,and the EDV in both groups increased compared with those before treatment,and the index in the observation group was higher than that in the control group,and the differences were statistically significant(P<0.05).After 1 week of treatment,WBHSV,WBLSV,BV and HCT of pregnant women in the two groups were decreased compared with before treatment,and the indexes in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:The treatment combining Low Molecular Weight Heparin,Compound Amino Acids,and Magnesium Sulfate significantly improves fetal development indicators and umbilical blood flow indexes,and reduces rates of preterm birth and fetal distress,thus having a positive impact on maternal and infant health.关键词
低分子肝素/复方氨基酸/硫酸镁/胎儿生长受限/胎儿脐血流指数Key words
Low Molecular Weight Heparin/Compound Amino Acids/Magnesium Sulfate/Fetal growth restriction/Umbilical blood flow indexes
