摘要
Abstract
Objective:To explore the effect of Guizhi Fuling Pills combined with Drospirenone Ethinylestradiol in the treatment of obese polycystic ovary syndrome(PCOS).Method:A total of 98 patients with obese PCOS who admitted to the Obstetrics and Gynecology Department of Putian First Hospital from June 2020 to January 2023 were selected as the study subjects,they were randomly divided into the control group(n=49)and the study group(n=49)using the random number table method.The control group was treated with Drospirenone Ethinylestradiol on the basis of symptomatic treatment,and the study group was treated with Guizhi Fuling Pills on the basis of the control group,the sex hormones[luteinizing hormone(LH),follicle-stimulating hormone(FSH),estrogen(E2),testosterone(T)],insulin resistance index[homeostatic model assessment of insulin resistance(HOMA-IR),fasting insulin(FINS)]before and after intervention,and ovulation rate and pregnancy rate after intervention were compared between two groups.Result:After intervention,the levels of LH,FSH,E2,T,FINS and HOMA-IR in two groups were decreased,and those in the study group were lower than those in the control group,the differences were statistically significant(P<0.05);the ovulation rate and pregnancy rate in the study group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Guizhi Fuling Pills combined with Drospirenone Ethinylestradiol in the treatment of obese PCOS can improve sex hormone levels,regulate insulin resistance,promote ovulation,and increase pregnancy rate.关键词
桂枝茯苓丸/屈螺酮炔雌醇/肥胖型多囊卵巢综合征/胰岛素抵抗Key words
Guizhi Fuling Pills/Drospirenone Ethinylestradiol/Obese polycystic ovary syndrome/Insulin resistance
