摘要
Abstract
Objective:To explore the correlation between magnetic resonance imaging(MRI)features,Ki-67 protein expression levels,and the degree of differentiation in endometrial cancer(EC),as well as to analyze the predictive value of MRI features and Ki-67 protein expression in determining the degree of tumor differentiation in patients with EC.Method:MRI image data and Ki-67 protein marker index of 72 patients with EC admitted to the First Affiliated Hospital of Soochow University from June 2020 to June 2023 were selected as the study objects.According to the classification criteria of EC differentiation,the patients were divided into three groups:highly differentiated(n=28)group,moderately differentiated group(n=31)and poorly differentiated(n=13)group.The clinical features,MRI features of different degrees of differentiation and Ki-67 protein expression level of different degrees of differentiation were compared among all groups.The predictive value of MRI features and Ki-67 protein expression on tumor differentiation in patients with EC was analyzed.Result:The cases of endometrium thickening,cervical interstitial infiltration,paracentral involvement,peritoneal metastasis and inguinal lymph node enlargement in differentiated group were higher than those in moderately differentiated and highly differentiated groups,and the Ki-67 protein marker index was significantly higher than that in moderately differentiated and highly differentiated groups,with statistical significance(P<0.05).MRI features and Ki-67 protein expression level were correlated with the differentiation degree of EC.The sensitivity and specificity of MRI features and Ki-67 protein expression were 84.62%and 95.00%respectively in predicting the differentiation degree of EC.Conclusion:By analyzing MRI features and Ki-67 protein expression levels of EC with different degrees of differentiation,it can effectively assist clinical diagnosis of EC differentiation to make a more accurate judgment.关键词
子宫内膜癌/磁共振成像/Ki-67蛋白/分化程度/预测Key words
Endometrial cancer/Magnetic Resonance imaging/Ki-67 protein/Degree of differentiation/Prediction
