摘要
Abstract
Objective:To investigate the effect of Sintlimab injection combined with chemotherapy in patients with advanced gastric cancer and its influence on immunity level.Method:A total of 82 patients with advanced gastric cancer in Nantong Tongzhou People's Hospital of City from January 2020 to February 2024 were selected as the subjects,and they were divided into two groups by envelope method,with 41 cases in each group.The control group was treated with chemotherapy(Teggio combined with oxaliplatin),while the observation group was treated with sindillimab injection.Tumor markers,T lymphocyte levels and safety of the two groups were compared.Result:The overall objective response rate(ORR)and disease control rate(DCR)of observation group were higher than those of control group,and the difference was statistically significant(P<0.05).After 3 courses of treatment,the level of tumor markers decreased between the two groups,and the difference was statistically significant(P<0.05).The levels of Carcinoembryonic antigen(CEA),carbohydrare antigen 19-9(CA19-9),carbohydrare antigen 242(CA242),alpha-fetoprotein(AFP)in the observation group were lower than those in the control group,with statistical significance(P<0.05).The levels of immunity were improved after three courses of treatment.The levels of CD3+,CD4+,and CD4+/CD8+in the observation group were higher than those in the control group,with statistical significance(P<0.05).The levels of CD8+in the observation group were lower than those in the control group,with statistical significance(P<0.05).And there was no statistical difference in the incidence of toxicities during the three courses of treatment(P>0.05).Conclusion:Sindilimab injection combined with chemotherapy can improve the therapeutic effect of patients with advanced gastric cancer,reduce the level of tumor markers,and improve the immune level of patients,but does not increase.关键词
信迪利单抗注射液/化疗/晚期胃癌/免疫水平/肿瘤标志物/毒副反应Key words
Sintilimab Injection/Chemotherapy/Advanced gastric cancer/Immune level/Tumor markers/Toxic side effects
