摘要
Abstract
Objective:To analyse the effect of amlodipine combined with metoprolol in the treatment of elderly patients with hypertension combined with coronary heart disease0.Method:Ninety-two elderly patients with hypertension combined with coronary heart disease treated in the Shanghai General Hospital Jiuquan Hospital n from April 2020 to September 2022 were selected as the study objects,and were divided into experimental group and reference group according to random number table method,with 46 cases in each group.Patients in both groups were given routine treatment,the reference group was given amlodipine alone,and the experimental group was given combined metoprolol on the basis of the reference group.The therapeutic effect of the two groups was compared.Result:After treatment,the diastolic blood pressure,systolic blood pressure,serum growth differentiation factor 15(GDF-15),lipoprotein a[Lp(α)],left ventricular ejection fraction(LVEF),left ventricular end-diastolic inner diameter(LVEDD),cardiac output(CO)and heart index(CI)of experimental groups were lower than those of reference group,with statistical significance(P<0.05).The clinical effective rate of experimental group was higher than that of reference group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Amlodipine combined with metoprolol can effectively control blood pressure level,reduce GDF-15 and Lp(α)levels,improve cardiac function,and do not increase the occurrence of adverse effects.关键词
氨氯地平/美托洛尔/老年/高血压合并冠心病/血清GDF-15/脂蛋白aKey words
Amlodipine/Metoprolol/Elderly/Hypertension with coronary heart disease/Serum GDF-15/Lipoprotein a
