中医药学报2025，Vol.53Issue(3)：61-66,6.DOI:10.19664/j.cnki.1002-2392.250054
防己黄芪汤对肥胖患者减重后体质量反弹及外周血Th1、Th2细胞水平变化的影响
Effects of Stephania Root and Astragalus Decoction on Weight Regain and Peripheral Blood Th1/Th2 Cell Levels in Obese Patients After Weight Loss
摘要
Abstract
Objective:To observe the effects of Stephania Root and Astragalus Decoction on weight regain and changes in peripheral blood Th1/Th2 cell levels in obese patients after weight loss.Methods:This study included 90 obese patients who successfully lost weight.They were randomly assigned to a control group(45 cases)and a treatment group(45 cases)using simple randomization.During the treatment,3 cases dropped out from the treatment group and 5 cases from the control group.The treatment group was given Stephania Root and Astragalus granules combined with lifestyle intervention,while the control group received only lifestyle intervention.The treatment duration was 3 months.Efficacy indicators such as body weight(including weight regain rate),waist circumference,BMI,insulin resistance index,HbA1c,blood lipids,and peripheral blood Th1/Th2 cell proportions and Th1/Th2 ratio were observed,as well as safety indicators such as liver and kidney function.Results:After treatment,the weight regain rate in the treatment group was 19.05%,which was significantly lower than 50.00%in the control group(P<0.01).The treatment group showed a statistically significant decrease in body weight,BMI,and waist circumference compared to before treatment(P<0.01).In contrast,the control group experienced a statistically significant increase in body weight,BMI,and waist circumference(P<0.05).The changes in body weight,BMI,and waist circumference were more pronounced in both groups(P<0.01).The treatment group showed a decrease in HOMA-IR,HbA1c,and total cholesterol compared to before treatment(P<0.05),while triglycerides,high-density lipoprotein,and low-density lipoprotein showed no significant changes(P>0.05).The control group showed an increase in HOMA-IR and triglycerides compared to before treatment(P<0.05),with no significant changes in HbA1c,total cholesterol,high-density lipoprotein,and low-density lipoprotein(P>0.05).The changes in HOMA-IR,total cholesterol,and triglycerides were significant in both groups(P<0.05,P<0.01),while the changes in HbA1c,high-density lipoprotein,and low-density lipoprotein were not significant(P>0.05).The treatment group showed a decrease in the proportion of peripheral blood Th1 cells compared to before treatment(P<0.01),an increase in Th2 cells(P<0.05),and a trend towards a decrease in Th1/Th2 ratio,although the difference was not statistically significant(P>0.05).The control group showed an increase in the proportion of peripheral blood Th1 cells(P<0.05),with no significant changes in Th2 cells and Th1/Th2 ratio(P>0.05).The change in Th1 cells was more significant in the treatment group compared to the control group(P<0.05),while the changes in Th2 cells and Th1/Th2 ratio were not significant between the two groups(P>0.05).After treatment,the total effective rate of TCM syndrome improvement in the treatment group was 85.71%,which was significantly higher than the 47.50%in the control group(P<0.01).There were no significant abnormalities in liver and kidney functions in either group.Conclusion:Stephania Root and Astragalus Decoction can reduce weight regain in obese patients after weight loss,further decrease body weight,waist circumference,and BMI,improve insulin resistance,blood glucose,and blood lipids,and lower the proportion of peripheral blood Th1 cells while increasing Th2 cells.It also improves patient symptoms and has good safety.关键词
防己黄芪汤/体质量反弹/肥胖记忆/随机对照研究Key words
Stephania Root and Astragalus Decoction/Weight regain/Obesity memory/Randomized controlled study分类
医药卫生引用本文复制引用
姜健,殷苏勤,刘曼曼,陈见纺,严军..防己黄芪汤对肥胖患者减重后体质量反弹及外周血Th1、Th2细胞水平变化的影响[J].中医药学报,2025,53(3):61-66,6.基金项目
上海市"十四五"中医特色专科项目(中医内分泌科)(ZYTSZK1-10) （中医内分泌科）
上海市嘉定区卫生健康委科研基金(2021-QN-ZYY-02) （2021-QN-ZYY-02）
嘉定区"疁城杏林"人才培养项目(JDLCX-LQNXZ-25) （JDLCX-LQNXZ-25）
