中医药学报2025，Vol.53Issue(3)：87-91,5.DOI:10.19664/j.cnki.1002-2392.250059
和胃解毒汤联合同步放化疗对食管癌骨髓抑制的影响
Effect of Hewei Jiedu Decoction Combined with Concurrent Chemoradiotherapy on Bone Marrow Suppression in Esophageal Cancer
摘要
Abstract
Objective:To observe the effect of Hewei Jiedu Decoction combined with concurrent chemoradiotherapy on bone marrow suppression in esophageal cancer.Methods:A total of 100 esophageal cancer patients treated at Meizhou People's Hospital from January 2020 to December 2022 were selected.They were randomly divided into two groups:the control group(50 cases,48 included in the final analysis after 2 dropped out)and the combination group(50 cases,47 included in the final analysis after 3 dropped out).The control group received intensity-modulated radiotherapy and TP chemotherapy regimen,while the combination group received Hewei Jiedu Decoction in addition to the treatment of the control group.After treatment,the clinical efficacy of both groups was compared.Chinese medicine syndrome scores before and after treatment were assessed,and the nutritional status of patients was evaluated using the Nutrition Risk Screening(NRS2002)scale.Serum levels of albumin,prealbumin,squamous cell carcinoma antigen(SCC),cytokeratin 19 fragment(CY-FRA21-1),NK cell subgroups(CD16+CD56+cells),T lymphocyte subgroups(CD4+cells,CD8+cells),and B lymphocyte subgroups(CD19+cells)were measured.The occurrence of adverse reactions in both groups was recorded.Results:The disease control rate and effective rate in the combination group were 97.87%(46/47)and 82.98%(39/47),respectively,while in the control group they were 83.33%(40/48)and 56.25%(27/48),respectively.The disease control rate and effective rate in the combination group were higher than those in the control group(P<0.05).The Chinese medicine syndrome score in the combination group was lower than that in the control group(P<0.05).The NRS2002 score in the combination group was lower than that in the control group(P<0.05).Serum albumin and prealbumin levels were higher in the combination group compared to the control group(P<0.05).The levels of CD4+cells in both groups decreased compared to before treatment(P<0.05),while the levels of CD16+CD56+cells,CD19+cells,and CD8+cells increased compared to before treatment(P<0.05).The levels of CD4+cells,CD16+CD56+cells,and CD19+cells were higher in the combination group compared to the control group(P<0.05),while the CD8+cell level was lower(P<0.05).SCC and CY-FRA21-1 expression levels in the combination group were lower than those in the control group(P<0.05).The incidence rates of bone marrow suppression,nausea and vomiting,and hair loss were lower in the combination group compared to the control group(P<0.05).Conclusion:Hewei Jiedu Decoction combined with concurrent chemoradiotherapy can regulate TBNK lymphocyte subgroups and nutritional indicators,reduce tumor marker levels,enhance therapeutic efficacy,and reduce the incidence of adverse reactions in patients with esophageal cancer.关键词
和胃解毒汤/同步放化疗/食管癌/TBNK淋巴亚群/营养/肿瘤标志物Key words
Hewei Jiedu Decoction/Concurrent chemoradiotherapy/Esophageal cancer/TBNK lymphocyte subgroups/Nutrition/Tumor markers分类
医药卫生引用本文复制引用
温嘉敏,黄清苑,林呼,曾志威..和胃解毒汤联合同步放化疗对食管癌骨髓抑制的影响[J].中医药学报,2025,53(3):87-91,5.基金项目
广东省中医药局科研项目(20191336) （20191336）
