中医药学报2025，Vol.53Issue(3)：92-96,5.DOI:10.19664/j.cnki.1002-2392.250060
补虚安神膏对阳虚体质不寐患者血清相关睡眠调节因子的影响
Effects of BuXu AnShen Ointment on Serum Sleep Regulatory Factors in Patients with Insomnia of Yang Deficiency Constitution
摘要
Abstract
Objective:To evaluate the efficacy of BuXu AnShen Ointment in treating patients with insomnia of Yang deficiency constitution and its effects on serum levels of serotonin(5-HT),gamma-aminobutyric acid(GABA),dopamine(DA),orexin-A(OXA),cAMP response element-binding protein(CREB),and circadian clock gene Period 1(PER1).Methods:A total of 159 patients with insomnia of Yang deficiency constitution were randomly divided into three groups:the ointment group,the Western medicine group,and the combination group,with 53 patients in each group.The ointment group was treated with BuXu AnShen Ointment,the Western medicine group was given eszopiclone,and the combination group received both BuXu AnShen Ointment and eszopiclone.The treatment duration was 4 weeks.The clinical efficacy and safety of the three groups were observed.Changes in Pittsburgh Sleep Quality Index(PSQI)scores,Yang deficiency constitution scores,and serum levels of 5-HT,GABA,DA,OXA,CREB,and PER1 were measured before and after treatment in all groups.Results:The overall efficacy rate in the combination group was 90.38%(47/52),which was higher than that of the ointment group(74.0%,37/50)and the Western medicine group(69.38%,34/49),with statistically significant differences(P<0.05).After treatment,PSQI scores in all groups decreased compared to pre-treatment levels(P<0.05,P<0.01),with the combination group showing a greater reduction than the ointment and Western medicine groups(P<0.05).Yang deficiency constitution scores in all groups decreased after treatment(P<0.05,P<0.01),and the ointment and combination groups showed a more significant decrease than the Western medicine group(P<0.01).After treatment,5-HT and GABA levels in all groups increased compared to pre-treatment levels(P<0.05,P<0.01),with the combination group showing a greater increase than the other two groups(P<0.05).DA levels in all groups decreased after treatment(P<0.05,P<0.01),with the combination group showing a greater decrease than the other two groups(P<0.05).OXA and CREB levels in all groups decreased after treatment(P<0.05,P<0.01),with the combination group showing a more significant decrease than the other two groups(P<0.01).PER1 levels in all groups increased after treatment(P<0.05,P<0.01),with the combination group showing a greater increase than the other two groups(P<0.01).No serious adverse reactions occurred in any group during the treatment.Conclusion:BuXu AnShen Ointment is effective and safe in treating insomnia of Yang deficiency constitution.It not only improves sleep quality but also corrects the biased constitution.Its mechanism of action may be related to the regulation of sleep-related factors.关键词
补虚安神膏/阳虚体质/不寐/睡眠调节因子Key words
Buxu Anshen Ointment/Yang deficiency constitution/Insomnia/Sleep regulatory factor分类
中医学引用本文复制引用
陈俊逾,王庆全,常春雷,史华勇,李星衡..补虚安神膏对阳虚体质不寐患者血清相关睡眠调节因子的影响[J].中医药学报,2025,53(3):92-96,5.基金项目
国家自然科学基金地区项目(82260915) （82260915）
新疆维吾尔自治区自然科学基金面上项目(2022D01C160) （2022D01C160）
新疆医科大学附属中医医院院级课题重点项目(ZYY2020ZD04) （ZYY2020ZD04）
