中医药学报2025，Vol.53Issue(3)：103-111,9.DOI:10.19664/j.cnki.1002-2392.250062
乌药化学成分研究、质量标志物预测分析及其药理作用的研究进展
Research Progress on the Chemical Constituents,Quality Marker Prediction,and Pharmacological Effects of Linderae Radix
摘要
Abstract
Linderae Radix,derived from the dried rhizome of Lindera angustifolia,a member of the Lauraceae family,has a long history of medicinal use,with its earliest record in the Supplement to the Materia Medica(Bencao Shiyi).The main chemical constituents of Linderae Radix include furan sesquiterpenoids and their lactones,essential oils,flavonoids,and isoquinoline alkaloids.This article collects and organizes relevant literature from the past 10 years to predict and analyze quality markers for Linderae Radix from multiple dimensions,including quality traceability,traditional medicinal theories,chemical detectability,and pharmacological actions.Based on scientific predictions,alkaloids like boldine,plant sterols,pentahydroxyflavone,dehydroiso-boldine,iso-lindera lactones,and lignan lactones have been identified as potential quality markers for Linderae Radix.Through a deep analysis of Linderae Radix's chemical constituents and quality markers,the herb is shown to possess a wide range of pharmacological effects,including anti-inflammatory and analgesic actions,anticancer,antioxidant properties,cardiovascular system regulation,prevention and treatment of diabetic nephropathy,and hepatoprotection.These findings provide a reference for understanding the current development and potential secondary development of Linderae Radix.关键词
乌药/化学成分/质量标志物/药理作用/研究进展Key words
Linderae Radix/Chemical constituents/Quality markers/Pharmacological effects/Research progress分类
中医学引用本文复制引用
赵淑睿,李力恒,张宇飞,李怡诺,袁有才,王仁帅,高杰..乌药化学成分研究、质量标志物预测分析及其药理作用的研究进展[J].中医药学报,2025,53(3):103-111,9.基金项目
国家自然科学基金青年科学基金项目(81202638) （81202638）
黑龙江省博士后科研启动基金(LBH-Q18115) （LBH-Q18115）
黑龙江省中医药科研项目(ZHY2024-012) （ZHY2024-012）
黑龙江省"双一流"学科协同创新项目(LJGXCG2024-P35) （LJGXCG2024-P35）
