中华中医药学刊2025，Vol.43Issue(2)：1-5,5.DOI:10.13193/j.issn.1673-7717.2025.02.001
心肾不交、肝郁气滞证围绝经期睡眠障碍女性微观指标比较
Comparison of Microscopic Indicators in Women with Perimenopausal Sleep Disorders of Non-Interaction between Heart and Kidney Syndrome and Liver Depression and Qi Stagnation Syndrome
摘要
Abstract
Objective To compare the disparities in the modified Kupperman s score(KMI)and peripheral blood micro indi-cators between non-interaction between heart and kidney syndrome and liver depression and Qi stagnation syndrome of perim-enopausal women experiencing sleep difficulties.Methods Eighty patients with perimenopausal sleep disorders were selected as research participants using the Pittsburgh Sleep Quality Index(PSQI).Among them,40 patients had non-interaction between heart and kidney syndrome and 40 patients had liver depression and Qi stagnation syndrome.The data,including traditional Chi-nese medicine syndrome collection forms and KMI scales was gathered.Enzyme-linked immunosorbent assay(ELISA)was used to quantify serum inflammatory markers[interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)]and neurotransmitter levels[gamma aminobutyric acid(GABA),glutamic acid(Glu)]in two groups.Results The study findings revealed that non-interaction between heart and kidney syndrome had higher values for time to fall asleep,sleep time,sleep efficiency,sleep disorder score and total PSQI score compared to the liver depression and Qi stagnation syndrome group(P＜0.05).Additionally,the liver depression and Qi stagnation syndrome group had a higher daytime dysfunction score than the non-interaction between heart and kidney syndrome group(P＜0.05).Furthermore,the non-interaction between heart and kidney syndrome group exhibited higher values for hot flashes,sweating,muscle and joint pain,palpitations,urinary system symptoms and total KMI score compared to the liver depression and Qi stagnation syndrome group(P＜0.05).Conversely,the liver depression and Qi stagnation syndrome group had higher scores for emotional excitement,depression,suspicion,dizziness,headache and skin ant sensation compared to the non-interaction between heart and kidney syndrome group(P＜0.05).Serum levels of IL-1 β and TNF-α were also higher in the liver depression and Qi stagnation syndrome group.The levels in the non-interaction between heart and kidney syndrome group were significantly higher than those in the other group(P＜0.05).In contrast,the serum GABA level in the non-interac-tion between heart and kidney syndrome group was lower than that in the liver depression and Qi stagnation syndrome group,while the Glu level was higher(P＜0.05).Conclusion In women experiencing sleep difficulties during the perimenopausal period,the non-interaction between heart and kidney syndrome is associated with worse overall sleep quality compared to the liver depres-sion and Qi stagnation syndrome.Additionally,the non-interaction between heart and kidney syndrome is also linked to more se-vere perimenopausal symptoms.The sleep disturbances and perimenopausal symptoms have distinct classifications.There are sig-nificant differences in the expressions of IL-1 β,TNF-α,GABA and Glu between the two syndromes,which may contribute to the objectivity and precision of traditional Chinese medicine syndrome differentiation for sleep disorders in perimenopausal women.关键词
围绝经期/睡眠障碍/中医辨证分型/炎症因子/神经递质Key words
perimenopause/sleep disorders/traditional Chinese medicine syndrome differentiation and classification/inflam-matory factors/neurotransmitters分类
医药卫生引用本文复制引用
冯晓玲,韩昕宇,陈铖,贾紫千..心肾不交、肝郁气滞证围绝经期睡眠障碍女性微观指标比较[J].中华中医药学刊,2025,43(2):1-5,5.基金项目
国家自然科学基金面上项目(81973894,82174421) （81973894,82174421）
