中医药信息2025，Vol.42Issue(3)：11-14,21,5.DOI:10.19656/j.cnki.1002-2406.20250303
不同炮制方法对香附中香附烯酮、α-香附酮含量及抗炎活性的影响
Effects of Different Processing Methods on the Content of Cyperone and α-Cyperone and Their Anti-Inflammatory Activities in Cyperi Rhizoma
摘要
Abstract
Objective:To investigate the effects of different processing methods on the content of Cyperone and α-Cyperone and their anti-inflammatory activities in Cyperi Rhizoma.Methods:A total of 32 batches of processed Cyperi Rhizoma were selected for each processing method:vinegar processing(vinegar group),four-stage processing(four-stage group),and wine processing(wine group),with 32 batches of raw Cyperi Rhizoma as the control group.The content of Cyperone and α-Cyperone in each sample was determined by HPLC.The influence of different processing methods on these compounds was compared.Meanwhile,the anti-inflammatory activity of each processed sample was preliminarily evaluated through in vitro cell experiments.Pearson correlation analysis was used to explore the relationship between the content of Cyperone and α-Cyperone and the levels of TNF-α,IL-1β,and IL-6.Results:The content of Cyperone in the vinegar group was lower than in the raw group but higher than in the four-stage and wine groups(P<0.05).The content of α-Cyperone in the vinegar group was higher than in the raw,four-stage,and wine groups(P<0.05).The anti-inflammatory experiment showed that the levels of TNF-α,IL-1β,and IL-6 in the vinegar group were significantly lower than in the raw,four-stage,and wine groups(P<0.05).Pearson correlation analysis showed that Cyperone and α-Cyperone were negatively correlated with TNF-α,IL-1β,and IL-6(P<0.05).Conclusion:After vinegar processing,the content of α-Cyperone in Cyperi Rhizoma was significantly higher than in the raw,four-stage,and wine groups,and it exhibited stronger anti-inflammatory activity.关键词
炮制方法/醋制/四制/酒制/香附/香附烯酮/α-香附酮/抗炎活性Key words
Processing methods/Vinegar processing/Four-stage processing/Wine processing/Cyperi Rhizoma/Cyperone/α-Cyperone/Anti-inflammatory activity引用本文复制引用
王跃华,张欢,陈展,刘延欣..不同炮制方法对香附中香附烯酮、α-香附酮含量及抗炎活性的影响[J].中医药信息,2025,42(3):11-14,21,5.基金项目
河南省中医药科学研究专项课题项目(2019ZY2036) （2019ZY2036）
