中医药信息2025，Vol.42Issue(3)：42-47,55,7.DOI:10.19656/j.cnki.1002-2406.20250308
从毛脉失和角度探讨动脉粥样硬化"膏脂-痰浊-痰结-痰瘀"证候演变特征
Exploring the Evolutionary Characteristics of"Grease-Phlegm Turbidity-Phlegm Concretion-Phlegm Stasis"Syndromes of Atherosclerosis Based on the Theory of Maomai Disharmony
摘要
Abstract
Maomai in harmony is the key process for the smooth flow of Qi and blood in the pulse,and the disorder of Maomai is an early manifestation of pulse diseases.Based on the theory of Maomai disorder,this article explores the evolutionary mechanism of the"grease-phlegm turbidity-phlegm concretion-phlegm stasis"syndromes in atherosclerosis(AS).By systematically analyzing relevant literature,the role of perivascular adipose tissue(PVAT)in the development of AS is revealed,with a focus on the interaction between vascular endothelial inflammation and PVAT,as well as the process of plaque formation and the development of vulnerable plaques.The study shows that the evolution of AS occurs in four stages:grease stage(normal spleen and stomach function,Qi and blood sufficiency);phlegm turbidity stage(spleen deficiency leading to phlegm accumulation,obstructed pulse);phlegm concretion stage(fat phlegm accumulation,blood stasis,structural changes in the pulse);phlegm stasis stage(phlegm and blood stasis interlocking,blood and vessel dysfunction).In addition,combining with imaging techniques,the microscopic structural changes of PVAT in each stage of AS were explored,and imaging techniques were proposed as a tool for the early diagnosis,risk assessment,and personalized treatment of AS.关键词
毛脉失和/膏脂/痰瘀/动脉粥样硬化/血管周围脂肪组织Key words
Maomai disorder/Grease/Phlegm stasis/Atherosclerosis/Perivascular adipose tissue引用本文复制引用
周婉宁,杨珺涵,齐雪杉,汪佳琪,朱烔依,王涵,李晓静,张哲..从毛脉失和角度探讨动脉粥样硬化"膏脂-痰浊-痰结-痰瘀"证候演变特征[J].中医药信息,2025,42(3):42-47,55,7.基金项目
国家中医药人才(青年岐黄学者)支持项目(20201A2180) （青年岐黄学者）
辽宁省科学技术计划项目(2020JH2/10300070) （2020JH2/10300070）
