阿尔茨海默病及相关病2025，Vol.8Issue(2)：81-91,11.DOI:10.3969/j.issn.2096-5516.2025.02.002
路易体痴呆血脑屏障通透性与血浆促食欲素A水平的关系
Association between blood-brain barrier permeability and plasma Orexin A level in Dementia with Lewy bodies
摘要
Abstract
Objective:To analyze the associations between blood brain barrier permeability and plasma orexin-A in Dementia with Lewy bodies(DLB).Methods:A total of 69 patients with probably DLB who were hospitalized in the cognitive impairment department,and 40 healthy controls in the health management center of Beijing Tiantan Hospital from January 2021 to December 2022 were retrospectively included.Demographic and clinical information and neuropsychological assessments were collected from medical records.Cerebrospinal fluid(CSF)levels of Aβ1-40,Aβ1-42,t-Tau and p-Tau181 and APOE genotypes were recorded.CSF/serum albumin quotient(Q-alb)was calculated to reflect the blood-brain barrier permeability,and plasma orexin-A levels were determined.Pearson and Partial correlation analysis were used to evaluate the associations between plasma orexin-A and Qalb.Results:The scores of MMSE(P<0.001)and MoCA(P<0.001)in DLB group were lower than those in control group,and CDR(P<0.001),ADL(P<0.001),NPI(P<0.001),and the levels of plasma orexin-A(P=0.015)and Qalb(P<0.001)were significantly higher than those of control group.In the control group,the plasma orexin-A level was significantly different in different body mass index(BMI,P=0.034)and whether there was a history of hypertension(P=0.049).Qalb level was different from BMI level(P=0.012).In DLB group,the plasma orexin-A level of subjects with stroke history was significantly lower than those without(P=0.025).Qalb levels were significantly higher in women than in men(P=0.034).In the control group,Pearson correlation and Partial correlation analysis showed a positive correlation between plasma orexin-A level and Qalb(Pearson correlation:r=0.589,P<0.001;Partial correlation:r=0.561,P<0.001).In DLB,Pearson correlation and Partial correlation analysis did not find significant correlation between plasma orexin-A level and Qalb and neuropsychological assessment scores(P>0.05).Conclusion:The plasma orexin-A and Qalb levels in patients with DLB were higher than controls.The elevated plasma orexin-A level in cognitively normal elderly people is associated to the increase of blood-brain barrier permeability,suggesting that the dysfunction of orexin-A system may be a potential mechanism of blood-brain barrier disorders..关键词
路易体痴呆/促食欲素/血脑屏障/脑脊液白蛋白/血清白蛋白比率Key words
Dementia with lewy bodies/Orexin/Blood-brain barrier/Cerebrospinal fluid albumin/serum albumin quotient分类
临床医学引用本文复制引用
甘景环,脱厚珍,张拥波,纪勇..路易体痴呆血脑屏障通透性与血浆促食欲素A水平的关系[J].阿尔茨海默病及相关病,2025,8(2):81-91,11.基金项目
国家自然科学基金资助项目(项目编号:82171182) （项目编号:82171182）
首都医科大学附属北京友谊医院"友谊种子计划"人才项目(项目编号:YYZZ202309) （项目编号:YYZZ202309）
首都医科大学培育(自然类)项目(项目编号:PYZ24081) （自然类）
