阿尔茨海默病及相关病2025，Vol.8Issue(2)：92-97,103,7.DOI:10.3969/j.issn.2096-5516.2025.02.003
阿尔茨海默病痴呆前阶段认知储备与认知功能的相关性研究
The relationship between cognitive reserve and cognitive function in the pre-dementia stage of Alzheimer's disease
摘要
Abstract
Objective:To investigate the effect of cognitive reserve(CR)proxy variables on cognitive function in pre dementia patients with Alzheimer's disease(AD).Methods:25 normal controls(NC)and 45 patients with mild cognitive impairment(MCI)were selected.All enrolled patients received Cognitive Reserve Index questionnaire(CRIq)to obtain the total score,education,work activities and leisure time scores,and completed the cognitive function scale assessment.Finally,correlation analysis and linear regression analysis were carried out on the proxy variables of cognitive reserve and the scores of each cognitive domain of the cognitive function scale.Results:① Total score,education and leisure time were positively correlated with Mini-mental State Examination(MMSE)score(r=0.506,P<0.001,r=0.398,P<0.001,r=0.448,P<0.001)and Montreal Cognitive Assessment(MoCA)score(r=0.492,P<0.001,r=0.353,P=0.002,r=0.403,P<0.001)reflecting overall cognition.② Education and number symbol conversion test,auditory word learning test,delayed recall and Boston Naming test were positively correlated(both P<0.05);The work activity was positively correlated with the number symbol test,the auditory word learning test,the delayed memory,and the number span positive memory test(both P<0.05).Leisure time was positively correlated with the total score of auditory word learning test and delayed recall,number span test,number symbol conversion test,animal word fluency and Boston naming test(both P<0.05).The total score was positively correlated with the total score of auditory word learning test and delayed recall,number span forward memorization test,animal word fluency test,number symbol conversion test and number span backward memorization test(both P<0.05).Conclusion:① There is a correlation between comprehensive cognitive reserve and overall cognitive function in AD patients in the pre-dementia stage.② Education level and lifelong leisure activities are correlated with the comprehensive cognitive scale,memory and language ability,while occupational complexity was correlated only with comprehensive cognitive scale and memory.关键词
轻度认知障碍/阿尔茨海默病/认知储备/认知功能Key words
Mild cognitive impairment/Alzheimer's disease/Cognitive reserve/Cognitive function分类
临床医学引用本文复制引用
李志,刘凤香,石林,包彩凤,史瑞仙,贾琪,梁芙茹..阿尔茨海默病痴呆前阶段认知储备与认知功能的相关性研究[J].阿尔茨海默病及相关病,2025,8(2):92-97,103,7.基金项目
北京师范大学认知神经科学与学习国家重点实验室开放性课题项目(CNLYB1702) （CNLYB1702）
内蒙古自治区神经系统疾病临床研究中心建设项目(2019P3084) （2019P3084）
内蒙古自治区包头市中心医院神经病学院士专家工作站资助项目(2017Y2001) （2017Y2001）
