阿尔茨海默病及相关病2025，Vol.8Issue(2)：98-103,6.DOI:10.3969/j.issn.2096-5516.2025.02.004
非药物干预对阿尔茨海默病患者认知功能影响的meta分析
A meta-analysis of the effects of non-pharmacological intervention on cognitive function in Alzheimer's disease patients
摘要
Abstract
Objective:To evaluate the effect of non-pharmacological intervention in AD patients.Methods:Relevant Chinese and English databases were searched to collect randomized controlled trials of non-drug intervention effect in Alzheimer's disease patients and conduct statistical treatment using Review Manager 5.3 software.Results:In 7 articles,non-pharmacological intervention improved the Mini-Mental State Examination(MMSE)score of Alzheimer's patients(WMD=-1.91,95%CI:-3.10,-0.70,Z=3.13,P=0.002)and Activity of Daily Living Scale(ADL)score(WMD=-0.09,95%CI:-0.86,0.67,Z=0.24,P=0.81).Conclusion:Compared with drug intervention or control measures,non-drug intervention can improve the intelligence and daily living function of Alzheimer's disease patients to a certain extent,but more long-term clinical data with large sample size are still needed for further verification.关键词
阿尔茨海默病/非药物疗法/药物疗法/随机对照试验Key words
Alzheimer's disease/Non-drug therapy/Drug therapy/Randomized controlled trial分类
临床医学引用本文复制引用
石雨珂,娄夏菁,王冰升,汪彬,姜海燕,康俊玲,曹世华..非药物干预对阿尔茨海默病患者认知功能影响的meta分析[J].阿尔茨海默病及相关病,2025,8(2):98-103,6.基金项目
浙江省医药卫生科技计划项目(2022KY1052) （2022KY1052）
浙江省中医药传承创新项目(2023ZX0950) （2023ZX0950）
