摘要
Abstract
Objective:To observe the clinical effect of butylphthalide soft capsule combined with donepezil tablets in the treatment of patients with post-stroke cognitive impairment(PSCI).Methods:Sixty patients with PSCI were randomly divided into treatment group and control group,30 patients in each group.The control group was given oral donepezil tablets,one tablet after meals(10 mg)every night,and the treatment group was given oral butylphthalide soft capsules on the basis of the control group,taking 2 capsules before meals,0.2 g each.All patients were treated for 4 weeks.The levels of mini-mental state examination(MMSE),Montreal cognitive test(MoCA),modified Barthel index(MBI)and brain-derived neurotrophic factor(BDNF)were measured before and after treatment.The data were recorded and analyzed.Results:After treatment,the MMSE,MoCA and MBI scores of the two groups were higher than those before treatment,and the scores of the treatment group were higher than those of the control group,the differences were statistically significant(P<0.05).After treatment,there was no significant difference in the BDNF level of the control group compared with that before treatment,while the BDNF level of the treatment group was significantly higher than that before treatment and that of the control group(P<0.05).Conclusion:Butylphthalide soft capsule combined with donepezil tablets is superior to donepezil tablets alone in the treatment of PSCI.The combined treatment can improve the cognitive function and daily living ability of PSCI patients faster,which is worthy of further clinical recommendation.关键词
卒中后认知障碍/丁苯酞软胶囊/多奈派齐片/简明精神状态量表/蒙特利尔认知测试/改良Barthel指数/脑源性神经营养因子Key words
Post-stroke cognitive impairment/Butylphthalide soft capsule/Donepezil tablets/Mini-mental State Examination/Montreal Cognitive Assessment/Modified Barthel index/Brain-derived neurotrophic factor分类
临床医学
