阿尔茨海默病及相关病2025，Vol.8Issue(2)：113-119,7.DOI:10.3969/j.issn.2096-5516.2025.02.007
载脂蛋白E与阿尔茨海默病2009-2023年文献计量与可视化分析
Bibliometric and visual analysis of apolipoprotein E and Alzheimer's disease from 2009 to 2023
摘要
Abstract
Objective:This study aims to apply bibliometric methods to explore the global and domestic research status,trends,and emerging topics related to apolipoprotein E(APOE)and Alzheimer's disease(AD)from 2009 to 2023.Methods:We searched the Web of Science for literature on APOE and Alzheimer's disease from January 2009 to December 2023.The retrieved data were analyzed using CiteSpace(6.2.R6)software,with visualizations generated for authors,keywords,countries,institutions,and more.Results:From 2009 to 2023,the number of research articles on APOE and Alzheimer's disease increased steadily,with a total of 4,452 publications.The United States had the highest volume of publications.Keyword co-occurrence and clustering analyses revealed"APOE""mild cognitive impairment"and"age"as major research topics globally.Conclusion:Future research on APOE and AD will primarily focus on the genetic phenotypes of APOE and their relationship with AD,as well as exploring clinical applications of treatments targeting APOE phenotypes or altering these phenotypes to treat AD.关键词
阿尔茨海默病/文献计量学/载脂蛋白E/CiteSpace/可视化分析Key words
Alzheimer's disease/Bibliometrics/Apolipoprotein E/CiteSpace/Visual analysis分类
临床医学引用本文复制引用
王思凯,姚帅锋,陈雨潇,姜晓璩,蔡静..载脂蛋白E与阿尔茨海默病2009-2023年文献计量与可视化分析[J].阿尔茨海默病及相关病,2025,8(2):113-119,7.基金项目
贵州省中医药管理局中医药、民族医药科学技术研究课题(QZYY2017-039) （QZYY2017-039）
贵州省科技计划项目(黔科合基础-ZK[2022]一般519) （黔科合基础-ZK[2022]一般519）
贵州中医药大学研究生教育创新计划自然科学项目建设任务(YCXZR2021008) （YCXZR2021008）
贵州中医药大学2021年研究生教育创新计划项目(黔科合基础-ZK[2022]一般519) （黔科合基础-ZK[2022]一般519）
