北京中医药2025，Vol.44Issue(2)：137-141,5.DOI:10.16025/j.1674-1307.2025.02.005
麻附益肾方治疗中、高风险膜性肾病的临床疗效观察
Clinical efficacy of Mafu Yishen Decoction in treating intermediate-and high-risk membranous nephropathy
摘要
Abstract
Objective To evaluate the efficacy and safety of Mafu Yishen Decoction in the treatment of intermediate-and high-risk membranous nephropathy(MN)with external cold and internal deficiency,cold coagulation,and stasis accumulation syndrome through a real-world study.Methods Clinical data were collected from intermediate-and high-risk MN patients who received Mafu Yishen Decoction treatment at the Department of Nephrology,Beijing Hospital of Traditional Chinese Medicine,between 2016 and 2022.The primary outcome was a composite endpoint of complete or partial remission.Secondary outcomes included 24-hour urine protein quantification(UTP),serum albumin(ALB),serum creatinine(SCr),estimated glomerular filtration rate(eGFR),and other clinical manifestations of nephrotic syndrome.Results ①A total of 152 MN patients were included,comprising 36 with intermediate risk and 116 with high risk.The median treatment duration was 48.0(34.8,63.6)months.② After Mafu Yishen Decoction treatment,75.7%(115/152)of patients achieved clinical remission,including 29.6%with complete remission and 46.1%with partial remission.The cumulative remission rates at 12,24,36,and 48 months were 30.9%,55.9%,66.4%,and 73.0%,respectively.③ Relapse occurred in 10.4%(12/115)of patients during follow-up;the time from remission to relapse was 14.5(7.5,22.5)months.④ After treatment,serum ALB increased from 26.0(22.4,30.2)g/L to 40.2(34.6,44.1)g/L(P<0.01),24-hour UTP decreased from 7.5(5.0,10.2)g to 1.1(0.1,3.9)g(P<0.01),and blood lipid levels significantly decreased(P<0.01).⑤No significant adverse reactions were observed during Mafu Yishen Decoction treatment.Conclusion MaFu YiShen Decoction can effectively improve the clinical symptoms and nephrotic syndrome status of patients with MN yang deficiency and symptomatic syndrome,with high safety and low recurrence rate.This therapy has the value of popularisation and application in clinical practice.关键词
膜性肾病/中医药/温阳解表法/麻附益肾方/回顾性研究Key words
membranous nephropathy/traditional Chinese medicine/assisting yang and releasing the external/Mafu Yishen Decoction/retrospective study引用本文复制引用
黄淑贤,芮宏亮,戴浩然,赵启涵,张乃芊,王晴,丁倩,刘宝利..麻附益肾方治疗中、高风险膜性肾病的临床疗效观察[J].北京中医药,2025,44(2):137-141,5.基金项目
首都卫生发展科研专项重点攻关项目(2024-1-2231) （2024-1-2231）
北京市科委首都特色项目(Z221100007422092) （Z221100007422092）
