西部中医药2025，Vol.38Issue(3)：36-41,6.DOI:10.12174/j.issn.2096-9600.2025.03.08
一种简便的临床决策模型
A Simple Clinical Decision Model:Analysis of Adverse Reaction Risk Factors of Xueshuantong Injection
摘要
Abstract
Objective:To discuss the potential risk factors of adverse reaction of Xueshuantong injection(XSTI)using the data collected in Lanzhou region,and to develop a simple tool for the prediction and management of its human factors,so as to provide the reference for clinical rational medication.Methods:A total of 1229 inpatient cases of applying XSTI were gathered in Lanzhou region,among them,23 cases suffered adverse reactions.115 medical cases were obtained after using propensity score matching(PSM)to match the confounder including gender,age,ethnic groups,body height and body mass in accordance with 1∶4,and these medical cases were analyzed using decision tree(DT)for modeling,and the importance of the respective variables was calculated using the random forest(RF)model.Results:The top four variables in terms of importance were number of combined drugs(NOCD),single dose per body surface area(DPBSA),IV drip rate(IV rate)and solution type(S type),and the mean Gini index reduction>3.7,was the most important risk factor.The variables exported from the final clinical prediction model were NOCD and DPBSA,which were closely related factors.Conclusion:Decision Tree model is a simple tool for predicting the risk of adverse reactions;NOCD and DPBSA are closely related to the incidence of adverse reaction of XSTI;The dose of XSTI administered should be calculated according to the body surface area method,and the dose administered per unit of body surface area should be<289.2 mg/m2.关键词
注射用血栓通/倾向性匹配/决策树/随机森林/单位体表面积给药剂量/不良反应/危险因素Key words
Xueshuantong injection/propensity score matching/decision tree/random forest/single dose per body surface area/adverse reaction/risk factors分类
医药卫生引用本文复制引用
肖正国,刘效栓,李喜香,刘军刚,张民,王炯,李莉,豆金彦,季文莹..一种简便的临床决策模型[J].西部中医药,2025,38(3):36-41,6.基金项目
2022年中央转移支付医疗服务与保障能力提升(中医药事业传承与发展部分)——中医药人才培养重点学科建设项目(甘财社[2022]48号). （中医药事业传承与发展部分）
