国际老年医学杂志2025，Vol.46Issue(2)：129-133,5.DOI:10.3969/j.issn.1674-7593.2025.02.001
线粒体低毒兴奋效应在衰老中作用的研究进展
Progress on the role of mitohormesis in aging
摘要
Abstract
Aging is closely related to mitochondria,and mitochondrial dysfunction plays an important role in aging,which is also a key cause of degenerative diseases.Mitochondria are essential for maintaining the stability of the intracellular environment,mo-nitoring cellular homeostasis,and can timely reverse transmit stress signals to the nucleus to achieve feedback regulation.Exposure to long-term low-intensity stress stimuli such as reactive oxygen species,accumulation of unfolded proteins,and disruptions of energy me-tabolism can activate the mitohormesis,triggering a compensatory response in cells to resist stress stimuli and improve cellular resili-ence,thereby promoting health and prolonging life.In degenerative diseases such as Alzheimer's disease,Parkinson's disease,and os-teoporosis,the mitohormesis can also be used as potential therapeutic targets.Therefore,it is of great significance to study the mito-hormesis to promote health,prolong life,delay aging,and prevent or treat degenerative diseases.关键词
活性氧/线粒体未折叠蛋白质反应/线粒体低毒兴奋效应/衰老/退行性疾病Key words
ROS/UPRmt/Mitohormesis/Aging/Degenerative diseases引用本文复制引用
陈宇轩,吴颖,张闻达,沈璐妍,董德录,孙连坤..线粒体低毒兴奋效应在衰老中作用的研究进展[J].国际老年医学杂志,2025,46(2):129-133,5.基金项目
国家自然科学基金青年科学基金项目(82102733) （82102733）
