国际老年医学杂志2025，Vol.46Issue(2)：146-149,4.DOI:10.3969/j.issn.1674-7593.2025.02.004
血清同型半胱氨酸对老年急性冠状动脉综合征患者经皮冠状动脉介入治疗后心血管不良事件的预测价值
The predictive value of serum homocysteine for adverse events after percutaneous coronary intervention in elderly patients with acute coronary syndrome
摘要
Abstract
Objective To investigate the predictive value of serum homocysteine(Hcy)for the occurrence of major adverse cardiovascular events(MACE)within 30 days after percutaneous coronary intervention(PCI)in elderly patients with acute coronary syndrome(ACS).Methods A prospective study was conducted in 153 elderly patients with acute coronary syndrome admitted to Changchun Central Hospital from October 2023 to March 2024.The patients were followed up for 30 days on the first day after PCI.The patients were divided into an occurrence group and a non-occurrence group according to the occurrence of MACE.Multivariate lo-gistic regression model was used to analyze the influencing factors of MACE,and ROC curve was used to analyze the predictive value of serum Hcy for the occurrence of MACE after PCI.Results Twenty-seven patients developed MACE,and the levels of Hcy,low den-sity lipoprotein cholesterol(LDL-C),and uric acid(UA)in the group that developed MACE were higher than those in the group that did not develop MACE(P<0.05);multivariate logistic regression analysis showed that Hcy,UA,and LDL-C were all independent risk factors for MACE after PCI in elderly patients with acute coronary syndrome(P<0.05);ROC curves showed that Hcy had a cer-tain predictive mechanism for MACE after PCI in elderly patients with acute coronary syndrome,with an area under the curve of 0.687(95%CI:0.558-0.815,P=0.002).Conclusion Serum Hcy is a risk factor for MACE in elderly patients with acute coronary syndrome in the short term after PCI,and it has some predictive value for the occurrence of MACE.关键词
同型半胱氨酸/急性冠状动脉综合征/经皮冠状动脉介入治疗/主要心血管不良事件Key words
Homocysteine/Acute coronary syndrome/Percutaneous coronary intervention/Major adverse cardiovascular e-vents引用本文复制引用
胡铧予,娄冬梅,鲁硕..血清同型半胱氨酸对老年急性冠状动脉综合征患者经皮冠状动脉介入治疗后心血管不良事件的预测价值[J].国际老年医学杂志,2025,46(2):146-149,4.基金项目
吉林省卫生健康科技能力项目(2023LC095) （2023LC095）
