医学分子生物学杂志2025，Vol.22Issue(2)：205-210,6.DOI:10.3870/j.issn.1672-8009.2025.02.016
肠道巨噬细胞在炎症性肠病发病机制中的研究进展
Research Progress of Intestinal Macrophages in Pathogenesis of In-flammatory Bowel Disease
薄佳佳 1郭婷婷 1申慧琴2
作者信息
- 1. 山西医科大学 太原市,030000
- 2. 山西医科大学第二医院消化内科 太原市,030001
- 折叠
摘要
Abstract
Inflammatory bowel disease(IBD)is a class of chronic recurrent gastrointestinal inflammatory diseases caused by inflammation and immune system disorders.Its pathogenesis is com-plex,and the immune system attacks the lining of the intestine,causing chronic inflammation and tissue damage.As a typical inflammatory disease,multiple immune cell types are involved in the pathogenesis of IBD.Among them,macrophages are thought to play a pivotal role.Intestinal macro-phages are an important part of maintaining intestinal immune homeostasis and inhibiting the inflam-matory response,which is of great significance for the treatment of inflammatory bowel dis-ease.Given that macrophages can coordinate inflammation resolution and tissue repair,they are cur-rently considered an attractive target for developing new treatments for inflammatory bowel dis-ease.This review summarizes the research progress of immunomodulatory role of intestinal macropha-ges in IBD,so as to provide reference for the research of pathogenesis and the clinical treatment of IBD.关键词
炎症性肠病/巨噬细胞/肠道/稳态Key words
inflammatory bowel disease/macrophage/intestinal/homeostasis分类
医药卫生引用本文复制引用
薄佳佳,郭婷婷,申慧琴..肠道巨噬细胞在炎症性肠病发病机制中的研究进展[J].医学分子生物学杂志,2025,22(2):205-210,6.
