中国实用神经疾病杂志2025，Vol.28Issue(3)：265-270,6.DOI:10.12083/SYSJ.240778
间充质干细胞素治疗阿尔茨海默病的临床研究
Clinical study on mesenchymal stem cell factors therapy for Alzheimer's disease
摘要
Abstract
Objective To investigate the therapeutic effect of mesenchymal stem cell factors(MSCF)on Alzheimer's disease(AD),and provide an effective method for prevention and treatment of AD.Methods Ninety patients were randomly divided into the conventional treatment group(control group I),MSCs(control group Ⅱ)and MSCF(observation group)with 30 patients per group.Enzyme-linked immunosorbent assay(ELISA)was used to detect the concentration of A β42 protein and tau in cerebrospinal fluid(CSF)at the time points of the three groups before and 1 month,3 months and 6 months after treatment.The three groups were scored by the Alzheimer's disease assessment scale-cognitive section(ADAS-cog)before treatment and 1 month,3 months and 6 months after treatment.Before treatment and 6 months after treatment,cerebral angiography and electroencephalogram were performed in the three groups.According to the clinical efficacy criteria,clinical efficacy of the three groups was evaluated after treatment.Results The concentration of Aβ42 protein and tau protein in the control group Ⅰ had no change before and after treatment(P＞0.05).The concentration of A β42 protein in the control group Ⅱ and the observation group increased gradually and the concentration of tau protein decreased significantly after treatment(P＜0.05).The indexes in the observation group were significantly better than those in the control group I and the control group Ⅱ(P＜0.05).The ADAS-cog scores of the three groups decreased significantly after treatment,and the ADAS-cog scores of the control group I returned to the level before treatment 6 months after treatment,and the ADAS-cog scores of the observation group were better than those of the control group Ⅱ(P＜0.05).After treatment,the results of cerebral angiography and EEG were improved in the three groups,and the observation group had the best improvement.Eighteen(60.00％)cases were effective,no cured cases in control group I;26 cases(86.67％)were effective,and 2 cases(6.70％)were clinically cured in the control group Ⅱ;30 cases(100.00％)were effective and 12 cases(40.00％)were clinically cured in the observation group.All indicators of observation group were significantly better than those of control group I and control group Ⅱ(P＜0.05).Conclusion MSCF can keep nerve cells alive.It can repair damaged nerve cells quickly,activate the functional nerve cells dormant in brain to participate in the physiological activities of brain,activate NSCs differentiation.MSCF treatment for AD is better effective than MSCs.关键词
阿尔茨海默病/间充质干细胞/间充质干细胞素/神经细胞/预防治疗/干细胞移植Key words
Alzheimer's disease/Mesenchymal stem cells factors/Mesenchymal stem cells/Nerve cell/Preventive and treatment/Stem cell transplantation分类
临床医学引用本文复制引用
谢培增,谢成,邓寅,孙成玲,陆培华,李元昊..间充质干细胞素治疗阿尔茨海默病的临床研究[J].中国实用神经疾病杂志,2025,28(3):265-270,6.基金项目
南京医科大学无锡医学中心2023年专病队列和临床研究项目(编号:WMCC202326) （编号:WMCC202326）
