中国实用神经疾病杂志2025，Vol.28Issue(3)：331-335,5.DOI:10.12083/SYSJ.240712
血清sICAM-1与HLA-DR对脑卒中患者隐性吸入性肺炎的预测价值
Prognostic value of serum sICAM-1 and HLA-DR for recessive aspiration pneumonia in stroke patients
摘要
Abstract
Objective To evaluate the diagnostic value of serum soluble intercellular adhesion molecule-1(sICAM-1)and human leukocyte antigen-DR(HLA-DR)in predicting silent aspiration pneumonia(SAP)in stroke patients.Methods A retrospective analysis was conducted on 80 stroke patients admitted to Henan Provincial People's Hospital from February 2023 to February 2024.The patients were divided into SAP group(n=28)and non-SAP group(n=52)based on the occurrence of SAP.Clinical characteristics and biochemical indicators of the two groups were compared,including sex,age,body mass index(BMI),blood pressure,alcohol history,smoking history,white blood cell count,neutrophil count,and serum levels of sICAM-1 and HLA-DR.Important indicators were selected through Lasso regression and their relationships with SAP were analyzed by ordinal Logistic regression.In addition,receiver operating characteristic(ROC)curves were used to assess the predictive values of sICAM-1 and HLA-DR.Results There were no significant differences between the SAP group and the non-SAP group in terms of sex,age,BMI,systolic and diastolic blood pressure,and alcohol history(P＞0.05).However,the SAP group showed significantly higher smoking history,white blood cell count,and neutrophil count(P＜0.05).Serum sICAM-1 levels were significantly higher and HLA-DR levels were significantly lower in the SAP group compared to the non-SAP group(P＜0.05).Multivariate Logistic regression analysis indicated that increased sICAM-1 and decreased HLA-DR were independent risk factors for SAP(P＜0.05).ROC curve analysis showed that the area under the curve(AUC)for sICAM-1 and HLA-DR in diagnosing SAP was 0.629 and 0.727,respectively,with sensitivity of 85.19％and 96.30％,and specificity of 82.59％and 80.74％,respectively.Combined diagnosis improved the AUC to 0.847,with sensitivity and specificity of 72.22％and 83.33％,respectively.Conclusion Serum sICAM-1 and HLA-DR are important biomarkers for predicting SAP in stroke patients,and the combined application has higher diagnostic value.关键词
隐性吸入性肺炎/脑卒中/可溶性细胞间黏附分子-1/人类白细胞抗原DR/血清/诊断价值/中性粒细胞Key words
Silent aspiration pneumonia/Stroke/sICAM-1/HLA-DR/Serum/Diagnostic value/Neutrophil分类
医药卫生引用本文复制引用
刘磊,侯婷婷,张文筱,张文学,尹艳霞..血清sICAM-1与HLA-DR对脑卒中患者隐性吸入性肺炎的预测价值[J].中国实用神经疾病杂志,2025,28(3):331-335,5.基金项目
河南省医学科技攻关计划联合共建项目(编号:LHGJ20230795) （编号:LHGJ20230795）
