中国实用神经疾病杂志2025，Vol.28Issue(3)：341-345,5.DOI:10.12083/SYSJ.231428
血清炎症因子-铁代谢途径与癫痫患者停药后复发的交互作用
Interaction of serum inflammatory factor-iron metabolic pathway and relapse in epilepsy patients after drug withdrawal
摘要
Abstract
Objective To analyze the interaction between serum inflammatory factor-iron metabolism pathway and relapse of epilepsy patients after drug withdrawal.Methods From June 2018 to June 2021,213 patients with epilepsy of Handan Central Hospital were selected as the study objects.The patients were followed up for 1 year after discontinuing antiepileptic drugs.According to the follow-up results,the patients were divided into relapse group and non-relapse group.Serum inflammatory factors(tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),interleukin-6(IL-6))and iron metabolism(ferritin,serum iron,total iron binding capacity)were measured.Logistic regression analysis was used to analyze the risk factors affecting relapse after drug withdrawal in patients with epilepsy,and Spearman correlation analysis was used to analyze the correlation among serum TNF-α,IL-1 β,IL-6,ferritin,serum iron,total iron binding capacity and relapse after drug withdrawal in patients with epilepsy.Results Among the 213 patients,201 cases successfully stopped the drug at 1-year,and the success rate was 94.37％(201/213).During the follow-up,13 cases were lost to follow-up,with a loss rate of 6.47％(13/201).Complete follow-up records were obtained for 188 patients,among whom 56 cases relapsed during follow-up,with a recurrence rate of 29.79％(56/188).The onset age of recurrence group was＞18 years old,the frequency of pre-treatment episodes was＞5 times per year,the disease course,TNF-α,IL-1β,IL-6,ferritin and total iron binding capacity were higher than those of non-recurrence group(P＜0.05),and the serum iron level was lower than that of non-recurrence group(P＜0.05).Logistic regression analysis showed that age of onset＞18 years old,frequency of seizures＞5 times per year before treatment,course of disease,TNF-α,IL-1 β,IL-6,ferritin,total iron binding capacity and abnormal serum iron level were risk factors for relapse after drug withdrawal in patients with epilepsy(P＜0.05).Serum levels of TNF-α,IL-1 β,IL-6,ferritin and total iron binding capacity were positively correlated with relapse after drug withdrawal in patients with epilepsy(P＜0.05),and serum iron level was negatively correlated with relapse after drug withdrawal in patients with epilepsy(P＜0.05).Conclusion The recurrence rate is higher in patients with epilepsy after drug withdrawal,and the serum levels of TNF-α,IL-1 β,IL-6,ferritin and total iron binding force are higher in patients with epilepsy recurrence,and the serum iron expression is decreased,and there is a significant correlation with epilepsy recurrence.The disorder of serum inflammatory factor-iron metabolism pathway may induce relapse in epilepsy patients after drug withdrawal,and the recurrence rate of epilepsy can be reduced by improving the above pathway clinically.关键词
癫痫/炎症因子/铁代谢/停药后复发/交互作用/血清Key words
Epilepsy/Inflammatory factors/Iron metabolism index/Relapse after drug withdrawal/Interaction/Serum分类
医药卫生引用本文复制引用
宋晓园,晁艳艳..血清炎症因子-铁代谢途径与癫痫患者停药后复发的交互作用[J].中国实用神经疾病杂志,2025,28(3):341-345,5.基金项目
邯郸市科学技术研究与发展计划项目(编号:19422083009-3) （编号:19422083009-3）
