中国实用神经疾病杂志2025，Vol.28Issue(3)：392-396,5.DOI:10.12083/SYSJ.231755
睡眠障碍与脑小血管病相关性的研究进展
Research progress on the correlation between sleep disorders and imaging features of cerebral small vessel disease
摘要
Abstract
Good sleep is essential for brain health.Chronic sleep disorders can lead to abnormalities in cerebrovascular structure and function.On the other hand,cerebral small vessel disease may also trigger sleep disorders.Current studies indicate that obstructive sleep apnea(OSA)is strongly associated with white matter hyperintensity and enlarged perivascular spaces.OSA leads to repeated hypoxemia,followed by blood-brain barrier disruption,chronic inflammation,excessive activation of sympathetic nerve and cerebral hemodynamic abnormalities,which may be the mechanism of the formation of white matter hyperintensities,while sleep structure abnormalities associated with OSA might contribute to the formation of enlarged perivascular spaces.Among non-respiratory sleep disorders,poor sleep quality is associated with cerebral small vessel disease,especially white matter hyperintensity and enlarged perivascular spaces.Restless legs syndrome may be associated with lacunae.There were limited researches on the relationship between excessive daytime sleepiness,periodic limb movements and cerebral small vessel disease,and the conclusions were inconsistent,which remains to be confirmed by further clinical studies.关键词
脑小血管病/睡眠呼吸暂停/日间过度嗜睡/不宁腿综合征/周期性肢体运动Key words
Cerebral small vessel disease/Obstructive sleep apnea/Excessive daytime sleepiness/Restless legs syndrome/Periodic limb movements分类
临床医学引用本文复制引用
焦立影,郭宇宙..睡眠障碍与脑小血管病相关性的研究进展[J].中国实用神经疾病杂志,2025,28(3):392-396,5.基金项目
内蒙古医科大学青年创新基金项目(编号:YKD2020QNCX010) （编号:YKD2020QNCX010）
内蒙古医科大学附属医院院级项目—科研联合基金、内蒙古自治区神经系统疾病临床医学研究中心项目资助、首府地区高质量发展优势临床重点专科神经系统疾病资助项目(编号:2023NYFY LHYB002) （编号:2023NYFY LHYB002）
