湖南中医药大学学报2025，Vol.45Issue(3)：523-528,6.DOI:10.3969/j.issn.1674-070X.2025.03.020
宣白承气汤对湿热蕴结型结直肠癌术后患者康复效果的影响
Effects of Xuanbai Chengqi Decoction on rehabilitation of patients with colorectal cancer of damp-heat pattern after surgery
摘要
Abstract
Objective To investigate the effects of Xuanbai Chengqi Decoction(XBCQD)on rehabilitation of patients with colorectal cancer of damp-heat pattern after surgery.Methods A total of 100 postoperative patients with colorectal cancer of damp-heat pattern from December 2021 to December 2023 at Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University were divided into two groups by random number table method,with 50 cases in each group.The control group received standard treatment during the perioperative period,while the observation group received oral XBCQD preoperatively for a course of seven days in addition to the standard treatment provided to the control group.The postoperative gastrointestinal function recovery,Chinese medicine(CM)pattern scores and levels of immune factors[granulocyte-macrophage colony-stimulating factor(GM-CSF),nucleotide-binding oligomerization domain-like receptor 3(NLRP3),and toll-like receptor 4(TLR4)],lung function[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),and FEV1/FVC],scores on European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30(EORTC QLQ-C30),efficacy in CM pattern,and incidence of complications were compared between two groups of patients.Results After treatment,the observation group had a shorter recovery time for postoperative gastrointestinal function compared to the control group(P<0.01).Compared with before the surgery,in both groups,the scores of each item and the total score of CM pattern,as well as the serum levels of NLRP3 and TLR4 at seven days after the surgery decreased(P<0.05),while the scores of each dimension of the EORTC QLQ-C30,the levels of GM-CSF,FEV1,FVC,and FEV1/FVC increased(P<0.05).Moreover,the CM pattern scores,the serum levels of NLRP3 and TLR4 in the observation group were lower than those in the control group(P<0.05),while the scores of each dimension of the EORTC QLQ-C30,the levels of GM-CSF,FEV1,FVC,and FEV1/FVC were higher than those in the control group(P<0.05).The total effective rate of the observation group was 96.00%,which was higher than 84.00%of the control group(P<0.05).The incidence of complications in the observation group was 4.00%,lower than 16.00%of the control group(P<0.05).Conclusion The preoperative application of XBCQD can effectively alleviate the postoperative clinical symptoms of colorectal cancer patients,with remarkable effects in promoting gastrointestinal function recovery and enhancing immune function and lung function.It can effectively reduce the risk of postoperative complications and improve the quality of life of patients.关键词
结直肠癌/宣白承气汤/胃肠功能/肺功能/免疫功能/临床疗效Key words
colorectal cancer/Xuanbai Chengqi Decoction/gastrointestinal function/lung function/immune function/clini-cal efficacy分类
医药卫生引用本文复制引用
于淼,路夷平,陈谦,张洪海,梁燕凯,冀祯..宣白承气汤对湿热蕴结型结直肠癌术后患者康复效果的影响[J].湖南中医药大学学报,2025,45(3):523-528,6.基金项目
北京市属医院科研培育计划项目(PZ2022008). （PZ2022008）
