湖南中医药大学学报2025，Vol.45Issue(3)：529-533,5.DOI:10.3969/j.issn.1674-070X.2025.03.021
银杏内酯B注射液对ITP患者T细胞亚群、MDSCs免疫失衡的影响
Effects of ginkgolide B injection on immune imbalance of T cell subsets and MDSCs in ITP patients
摘要
Abstract
Objective To investigate the effects of ginkgolide B injection on immune imbalance of T cell subsets and myeloid-derived suppressor cells(MDSCs)in patients with primary immune thrombocytopenia(ITP).Methods A total of 132 ITP patients admitted to Langfang TCM Hospital from December 2021 to December 2023 were selected as the research objects and were randomly divided into a study group(n=66)and a control group(n=66).The control group received rituximab treatment,while the study group was treated with ginkgolide B injection.The treatment cycle for both groups was 14 d.The therapeutic efficacy was compared between the two groups.The levels of Th1/Th2 cytokines[tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),interleukin(IL)-4,IL-10],MDSCs,and Treg/Th17 were compared before and after treatment between the two groups.The incidence of adverse reactions was also compared between the two groups.Results During the research process,three patients in the control group and one patient in the study group withdrew from the study.Ultimately,63 patients were included in the control group and 65 in the study group.The overall effective rate of treatment in the study group(95.38%)was higher than that in the control group(74.60%)(P<0.05).After treatment,TNF-α,IFN-γ,and Th17 levels decreased in both groups(P<0.05),while the levels of IL-4,IL-10,MDSCs,and Treg,as well as the Treg/Th17 increased(P<0.05).Compared with the control group,the study group had lower levels of TNF-α,IFN-γ,and Th17(P<0.05)and higher levels of IL-4,IL-10,MDSCs,and Treg,as well as the Treg/Th17(P<0.05).The overall incidence of adverse reactions in the study group(9.23%)was lower than that in the control group(26.98%)(P<0.05).Conclusion Ginkgolide B injection for the treatment of ITP patients can improve clinical therapeutic efficacy,alleviate the immune imbalance of Th1/Th2 cytokines and MDSCs,and does not increase the incidence of adverse reactions.关键词
原发免疫性血小板减少症/银杏内酯B注射液/Th1/Th2细胞因子/髓源性抑制细胞/调节性T细胞/辅助性T细胞17Key words
primary immune thrombocytopenia/ginkgolide B injection/Th1/Th2 cytokines/myeloid-derived suppressor cells/regulatory T cells/T helper 17 cells分类
医药卫生引用本文复制引用
张宝君,杨亚丽,雷蕊..银杏内酯B注射液对ITP患者T细胞亚群、MDSCs免疫失衡的影响[J].湖南中医药大学学报,2025,45(3):529-533,5.基金项目
河北省中医药管理局2023年度中医药类科学研究课题计划项目(2023231). （2023231）
