菌物学报Issue(3)：9-28,20.DOI:10.13346/j.mycosystema.240222
树舌灵芝三萜和杂萜化合物及其药理作用研究进展
Research progress of the pharmacological effects of triterpenoids and meroterpenoids from Ganoderma applanatum
摘要
Abstract
Ganoderma applanatum is one of the important medicinal fungi found in China,with a long history of medicinal and clinical application in China and East Asia.Ganoderma triterpenes are tetracyclic derivatives of lanostane,and they have been considered to be the main secondary metabolites and functional components of G.applanatum.Ganoderma triterpenoids have various chemical structures,and 7,8-epoxy-9(11)-ene-12-oxo-ganoderma triterpenoid is one of the characteristic secondary metabolites that distinguish G.applanatum from other species in this genus.With the recent continued discovery of various types of meroterpenoids,it has been shown that these compounds are another important kind of secondary metabolites in G.applanatum.They possess novel and diverse structures,including 10-carbon-chain,lactone-containing,pentacyclic/hexacyclic/heptacyclic,bridged,nitrogen-containing and dimeric meroterpenoids.Their different structural features determine the diverse pharmacological activities of G.applanatum.In addition,these compounds have been reported to have liver-protecting,angiogenesis-promoting,neuroprotective,anti-adipogenic,anti-inflammatory as well as antibacterial pharmacological activities.This article summarizes the structures and pharmacological activities of 98 naturally occurring triterpenoids and 67 meroterpenoids reported in the literature,aiming at providing a reference for further studies and development of G.applanatum.关键词
树舌灵芝/三萜/杂萜/药理活性Key words
Ganoderma applanatum/triterpenoids/meroterpenoids/pharmacological effects引用本文复制引用
邹录惠,邱平,张寒翠,熊桂玉,谢集照..树舌灵芝三萜和杂萜化合物及其药理作用研究进展[J].菌物学报,2025,(3):9-28,20.基金项目
广西自然科学基金(2023GXNSFAA026286) （2023GXNSFAA026286）
国家自然科学基金(81560627)This work was supported by the Guangxi Natural Science Foundation(2023GXNSFAA026286)and the National Natural Science Foundation of China(81560627). （81560627）
