菌物学报Issue(3)：111-123,13.DOI:10.13346/j.mycosystema.240270
虫生真菌棒状紫孢菌Purpureocillium clavatum的次级代谢产物
Secondary metabolites of the entomopathogenic fungus Purpureocillium clavatum(Ophiocordycipitaceae,Hypocreales)
摘要
Abstract
Large-scale fermentation of rice by the entomopathogenic fungus Purpureocillium clavatum was carried out,and the crude extract was separated and purified by several modern natural product separation methods.The structure of the compound was identified by nuclear magnetic resonance(NMR),mass spectrometry(MS),circular dichroism(CD)and other spectroscopic methods.Seven compounds were obtained from the ethyl acetate layer of the rice fermented extract of the entomopathogenic fungus Purpureocillium clavatum,including one new compound,purcilliumene A(5),four steroid compounds(1-3,6),one sphingosine compound(7),one other compound(4).Antimicrobial activity screening revealed that compounds 1,2,3,6,7 showed significant inhibitory effects against Coll etotri chum capsici,Hypomyces odoratus-Ⅰ,and Trichothecium roseum.Compounds 2 and 7 also showed inhibitory effect against Mycobacterium tuberculosis.关键词
棒状紫孢菌/次级代谢产物/抗菌活性/结核分枝杆菌Key words
Purpureocillium clavatum/secondary metabolite/antimicrobial activity/Mycobacterium tuberculosis引用本文复制引用
王易,张娴,彭兴灿,肖沅嫔,杨雨,刘正慧,黄启凤,文庭池..虫生真菌棒状紫孢菌Purpureocillium clavatum的次级代谢产物[J].菌物学报,2025,(3):111-123,13.基金项目
国家自然科学基金(32060012) （32060012）
贵州省科学技术基金[(2019)2451-3]This work was supported by the National Natural Science Foundation of China(32060012)and the Science and Technology Foundation of Guizhou Province[(2019)2451-3]. （2019）
