临床肝胆病杂志2025，Vol.41Issue(3)：409-414,6.DOI:10.12449/JCH250303
人血白蛋白在肝硬化及其并发症中的应用
The application of human serum albumin in liver cirrhosis and its complications
摘要
Abstract
Albumin is synthesized in the liver,and in case of severe liver injury,albumin synthesis is reduced with structural alterations(such as an increase in methylation and glycosylation),leading to a significant reduction in effective albumin in circulation.Albumin not only maintains plasma oncotic pressure,but also has the functions of antioxidation,anti-inflammation,immunomodulation,and transport.Current guidelines recommend the short-term application of human serum albumin in the treatment of large-volume paracentesis,hepatorenal syndrome,and spontaneous bacterial peritonitis in patients with liver cirrhosis,as it is shown that human serum albumin can help to reduce mortality.In addition,human serum albumin may improve the prognosis of cirrhotic patients with hyponatremia,non-SBP infections,and hepatic encephalopathy.However,there are still controversies over the application of human serum albumin in liver cirrhosis and related complications in terms of optimal dose and long-term efficacy.关键词
白蛋白类/肝硬化/腹水/肝肾综合征/肝性脑病/治疗学Key words
Albumins/Liver Cirrhosis/Ascites/Hepatorenal Syndrome/Hepatic Encephalopathy/Therapeutics引用本文复制引用
李雅欣,丁惠国..人血白蛋白在肝硬化及其并发症中的应用[J].临床肝胆病杂志,2025,41(3):409-414,6.基金项目
首都卫生发展科研专项(2022-1-2181) Capital Medical Development and Research Fund(2022-1-2181) （2022-1-2181）
