临床肝胆病杂志2025，Vol.41Issue(3)：415-419,5.DOI:10.12449/JCH250304
基因工程人血清白蛋白的研发与应用
The development and application of genetically engineered human serum albumin
摘要
Abstract
Human serum albumin(HSA)is the most abundant protein in plasma and has many biological functions and clinical applications.An adequate and stable supply of functional HSA molecules that are easy to store and have a long half-life is still an unmet clinical need.Therefore,it is extremely necessary to develop alternative methods for large-scale production of HSA.Genetic engineering techniques can clone the HSA gene into microorganism,animal,and plant hosts for efficient expression,which provides new possibilities for the large-scale production of HSA.This article reviews the advances in recombinant HSA(rHSA)in different expression systems and the production of rHSA by xenogeneic animals such as pigs and cattle,in order to draw attention to the application potential of genetic engineering techniques in HSA production and the importance of rHSA in the biomedical field in future.关键词
人血清白蛋白/肝疾病/基因工程Key words
Human Serum Albumin/Liver Diseases/Genetic Engineering引用本文复制引用
高沿航,牛俊奇..基因工程人血清白蛋白的研发与应用[J].临床肝胆病杂志,2025,41(3):415-419,5.基金项目
国家自然科学基金(U24A20654,82170602) （U24A20654,82170602）
吉林省中青年科技创新卓越人才项目(20220508079RC) （20220508079RC）
吉林省自然科学基金自由探索重点项目(YDZJ202401427ZYTS) （YDZJ202401427ZYTS）
吉林省肝脏代谢重点实验室(YDZJ202502CXJD002) （YDZJ202502CXJD002）
国家重点研发计划(2024YFE0213800) National Natural Science Foundation of China(U24A20654,82170602) （2024YFE0213800）
The Project for Middle-aged and Young Excellent Technological Innovation Talents of Jilin Province(20220508079RC) （20220508079RC）
Natural Science Foundation for Self-Exploration Research of Jilin Province(YDZJ202401427ZYTS) （YDZJ202401427ZYTS）
Jilin Provincial Key Laboratory of Metabolic Liver Diseases(YDZJ202502CXJD002) （YDZJ202502CXJD002）
National Key Research and Development Program of China(2024YFE0213800) （2024YFE0213800）
