临床肝胆病杂志2025，Vol.41Issue(3)：478-484,7.DOI:10.12449/JCH250313
硝酸甘油控制性低中心静脉压技术对腹腔镜肝切除肝癌患者脑代谢指标及脑血氧饱和度的影响
Effect of the nitroglycerin-controlled low central venous pressure technique on cerebral metabolic markers and cerebral blood oxygen saturation in patients undergoing laparoscopic hepatectomy for liver cancer
摘要
Abstract
Objective To investigate the effect of the nitroglycerin-controlled low central venous pressure(CLCVP)technique on brain metabolic markers and cerebral blood oxygen saturation in patients undergoing laparoscopic hepatectomy for liver cancer,and to reduce the risk of neurological complications.Methods A total of 105 patients who underwent elective laparoscopic hepatectomy for liver cancer in Haikou Hospital Affiliated to Xiangya Hospital of Central South University from April 2020 to May 2023 were enrolled and randomly divided into CLCVP group with 54 patients and non-CLCVP group with 51 patients.The patients in the CLCVP group were treated with the nitroglycerin CLCVP technique during surgery,while those in the non-CLCVP group were given conventional surgical treatment.The two groups were compared in terms of the following indicators:perioperative indicators;hemodynamic parameters and cerebral oxygen metabolism before anesthesia induction(T0),at 5 minutes after anesthesia induction(T1),at 5 minutes after the beginning of liver parenchyma dissection(T2),at 5 minutes after the end of hepatectomy(T3),and immediately after the end of surgery(T4);the changes in liver function parameters after surgery;the incidence rate of adverse reactions.The independent-samples t test was used for comparison of continuous data between two groups,and the chi-square test was used for comparison of categorical data between two groups;the analysis of variance with repeated measures was used for comparison between multiple time points.Results Compared with the non-CLCVP group,the CLCVP group had significantly lower intraoperative blood loss and intraoperative fluid infusion volume(t=5.408 and 7.220,both P<0.05),while there were no significant differences between the two groups in time of operation,anesthesia time,extubation time,resuscitation time and intraoperative urine volume(all P>0.05).Compared with the data at T0,both groups had significant reductions in mean arterial pressure,heart rate,and central venous pressure during surgery(all P<0.05),and compared with the non-CLCVP group,the CLCVP group had significantly lower mean arterial pressure and central venous pressure(P<0.05)and a significantly higher heart rate(P<0.05)at T2 and T3.Compared with the data at T0,both groups had a significant reduction in Ca-jvDO2 at T2—T4 time points(all P<0.05),while there was no significant difference in Ca-jvDO2 between the two groups at each time point(all P>0.05).Compared with the data at T0,the CLCVP group had a significant reduction in rSO2 at T2—T4 time points(all P<0.05),and the CLCVP group had a significantly lower level of rSO2 than the non-CLCVP group at T2—T3 time points(both P<0.05);there were no significant changes in CERO2 and Djv-aBL in either group at each time point(all P>0.05).At 3 and 7 days after surgery,both groups had significant increases in the liver function parameters of aspartate aminotransferase(AST),alanine aminotransferase(ALT),and total bilirubin(TBil)(all P<0.05),and the CLCVP group had significantly lower levels of AST and ALT than the non-CLCVP group(all P<0.05);there was no significant difference in TBil between the two groups at each time point(all P>0.05).There was no significant difference in the incidence rate of perioperative complications between the two groups(χ2=0.729,P=0.394).Conclusion The application of the nitroglycerin CLCVP technique in laparoscopic hepatectomy for liver cancer can reduce the amount of intraoperative blood loss in patients,but it is necessary to further enhance the monitoring of cerebral blood oxygen saturation during surgery,so as to reduce the risk of neurological complications as much as possible.关键词
硝酸甘油/控制性低中心静脉压/肝切除术/腹腔镜/对比研究Key words
Nitroglycerin/Controlling Low Central Venous Pressure/Hepatectomy/Laparoscopes/Comparative Study引用本文复制引用
王波,符霞,吕丛海,尹春芳,吴其远..硝酸甘油控制性低中心静脉压技术对腹腔镜肝切除肝癌患者脑代谢指标及脑血氧饱和度的影响[J].临床肝胆病杂志,2025,41(3):478-484,7.基金项目
海南省卫生健康行业科研项目(21A200328) （21A200328）
海南省自然科学基金(821RC1143) Research Project in Health and Healthcare Industry of Hainan Province(21A200328) （821RC1143）
Hainan Provincial Natural Science Foundation(821RC1143) （821RC1143）
