临床肝胆病杂志2025，Vol.41Issue(3)：547-551,5.DOI:10.12449/JCH250323
氨基酸代谢在自身免疫性肝炎中的作用机制及相关治疗靶点
Role of amino acid metabolism in autoimmune hepatitis and related therapeutic targets
摘要
Abstract
Autoimmune hepatitis(AIH)is a chronic inflammatory liver disease.The pathogenesis of AIH remains unclear,but it is mainly autoimmune injury caused by the breakdown of autoimmune tolerance due to the abnormal activation of the immune system,while the specific molecular mechanism remains unknown.Recent studies have shown that abnormal amino acid metabolism plays an important role in the development and progression of AIH.This article reviews the research advances in amino acid metabolic reprogramming in AIH,in order to provide a theoretical basis for amino acid metabolism as a new target for the clinical diagnosis and treatment of AIH.关键词
肝炎,自身免疫性/氨基酸类/分子靶向治疗Key words
Hepatitis,Autoimmune/Amino Acids/Molecular Targeted Therapy引用本文复制引用
郭佩佩,徐洋,石嘉琪,伍杨,卢利霞,李斌,于晓辉..氨基酸代谢在自身免疫性肝炎中的作用机制及相关治疗靶点[J].临床肝胆病杂志,2025,41(3):547-551,5.基金项目
甘肃省科技计划项目青年科技基金(23JRRA1675) （23JRRA1675）
甘肃省科技计划项目重点研发计划-社发类(22YF7FA105) Gansu Province Science and Technology Plan Project Youth Science and Technology Fund(23JRRA1675) （22YF7FA105）
Gansu Province Science and Technology Plan Project Key Research and Development Program-Social Development Category(22YF7FA105) （22YF7FA105）
