临床肝胆病杂志2025，Vol.41Issue(3)：568-573,6.DOI:10.12449/JCH250327
肠道菌群及其代谢物在慢加急性肝衰竭发生发展中的作用
Effect of intestinal flora and metabolites on the development and progression of acute-on-chronic liver failure
摘要
Abstract
Acute-on-chronic liver failure(ACLF)is a dangerous disease with severe conditions,rapid progression,and high short-term mortality.Intestinal flora and metabolites are closely associated with the development,progression,and pathogenesis of ACLF.During the development of ACLF,the destruction of intestinal integrity and the dysregulation of intestinal microecology and its metabolites mediate immune disturbance and thus aggravate systemic inflammatory response.This article elaborates on the role of intestinal flora and metabolites in the development and progression of ACLF and related therapeutic strategies.关键词
胃肠道微生物组/代谢/慢加急性肝功能衰竭Key words
Gastrointestinal Microbiome/Metabolism/Acute-On-Chronic Liver Failure引用本文复制引用
时克,张群,王宪波,冯颖..肠道菌群及其代谢物在慢加急性肝衰竭发生发展中的作用[J].临床肝胆病杂志,2025,41(3):568-573,6.基金项目
国家中医药管理局高水平中医药重点学科建设项目(zyyzdxk-2023005) （zyyzdxk-2023005）
首都卫生发展科研专项(首发2024-1-2173) （首发2024-1-2173）
第七批全国老中医药专家学术经验继承工作 （）
北京中医药科技发展资金项目(BJZYYB-2023-06) （BJZYYB-2023-06）
北京市自然科学基金面上项目(7232272) Construction Project of High-level Key Disciplines of Traditional Chinese Medicine of National Administration of Traditional Chinese Medicine(zyyzdxk-202300) （7232272）
Capital's Funds for Health mprovement and Research(CFH2024-1-2173) （CFH2024-1-2173）
Seventh Batch of National Traditional Chinese Medicine Experts Academic Experience Inheritance Program （）
Beijing Traditional Chinese Medicine Technology Development Fund Project(BJZYYB-2023-06) （BJZYYB-2023-06）
Beijing Municipal Natural Science Foundation(7232272) （7232272）
