临床肝胆病杂志2025，Vol.41Issue(3)：574-579,6.DOI:10.12449/JCH250328
肝衰竭肠道屏障损伤与环鸟苷酸-腺苷酸合酶(cGAS)-干扰素基因刺激因子(STING)信号通路的关系
Association between intestinal barrier disruption in liver failure and the cGAS-STING signaling pathway
摘要
Abstract
Liver failure is a common severe syndrome of liver diseases with high mortality.The function and structural integrity of the intestinal barrier as an entity are closely associated with the development and progression of liver failure.The cGAS-STING signaling pathway can participate in innate immune response by recognizing DNA produced by pathogen invasion and host cell damage and inducing the production of type I interferon.Numerous studies have shown that activation of the cGAS-STING pathway can significantly impact the cellular structure,mucosal components,and commensal bacteria of the intestinal barrier.This article reviews the interplay between the cGAS-STING signaling pathway and intestinal barrier disruption in liver failure,in order to provide novel insights for the clinical management of liver failure.关键词
肝功能衰竭/胃肠道微生物组/信号通路Key words
Liver Failure/Gastrointestinal Microbiome/Signaling Pathway引用本文复制引用
唐巧,周超,张宁,宫嫚..肝衰竭肠道屏障损伤与环鸟苷酸-腺苷酸合酶(cGAS)-干扰素基因刺激因子(STING)信号通路的关系[J].临床肝胆病杂志,2025,41(3):574-579,6.基金项目
"十三五"国家科技重大专项课题(2018ZX10725-505-001-010) （2018ZX10725-505-001-010）
国家自然科学基金青年项目(82305067) Major National Science and Technology Projects in the 13th Five-Year Plan(2018ZX10725-505-001-010) （82305067）
Natural Science Foundation for the Youth of China(82305067) （82305067）
