临床肝胆病杂志2025，Vol.41Issue(3)：588-593,6.DOI:10.12449/JCH250330
胆-肠轴在肝内胆管癌发生发展中的作用机制
Mechanism of action of bile-gut axis in the development and progression of intrahepatic cholangiocarcinoma
摘要
Abstract
Intrahepatic cholangiocarcinoma is a malignant tumor with an extremely poor prognosis,and its pathogenesis is complex and remains unclear.In recent years,more and more studies have focused on the role of bile-gut axis in the development and progression of intrahepatic cholangiocarcinoma.Bile-gut axis refers to the complex interaction between bile and gut microbiota,including bile salt metabolism,dynamic changes of microbiota,inflammatory response,and immune system regulation.This article elaborates on the potential mechanisms of bile-gut axis in intrahepatic cholangiocarcinoma,especially gut microbiota dysbiosis,abnormal bile salt metabolism,chronic inflammatory response,and immune system interaction,this article aims to provide new perspectives and possible therapeutic targets for future research and promote the early diagnosis and effective treatment of intrahepatic cholangiocarcinoma.关键词
胆管上皮癌/胆-肠轴/胃肠道微生物组/胆盐代谢/炎症Key words
Cholangiocarcinoma/Bile-Gut Axis/Gastrointestinal Microbiome/Bile Salt Metabolism/Inflammation引用本文复制引用
俞雪,沈天皓,周诚,刘雨,李炜,蒋霆辉,朱永强,刘艳..胆-肠轴在肝内胆管癌发生发展中的作用机制[J].临床肝胆病杂志,2025,41(3):588-593,6.基金项目
上海市卫生健康委员会青年人才计划(2022YQ037) （2022YQ037）
上海市普陀区卫生健康系统科技创新项目计划(ptkwws202210) （ptkwws202210）
上海市普陀区中心医院临床匠才计划(2022-RCJC-07) Talent Program of Shanghai Municipal Health Commission(2022YQ037) （2022-RCJC-07）
Shanghai Putuo District Health System Science and Technology Innovation Project Plan(ptkwws202210) （ptkwws202210）
Shanghai Putuo Central Hospital Clinical Talent Program(2022-RCJC-07) （2022-RCJC-07）
