临床肝胆病杂志2025，Vol.41Issue(3)：594-600,7.DOI:10.12449/JCH250331
肝内胆管癌间质-免疫微环境内成分及其相互作用
Components of tumor stroma-immune microenvironment and their interactions in intrahepatic cholangiocarcinoma
张秋露 1李卓 2刘从容 1郭丽梅1
作者信息
- 1. 北京大学第三医院病理科/北京大学医学部病理系,北京 100191
- 2. 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院病理科,北京 100021
- 折叠
摘要
Abstract
Intrahepatic cholangiocarcinoma(ICC)is a highly malignant liver tumor,and due to the absence of symptoms in its early stage and the lack of effective treatment measures,patients tend to have an extremely low 5-year survival rate.The tumor stroma-immune microenvironment(TSIME)is a complex ecosystem that changes dynamically during tumorigenesis and evolution and consists of a variety of cellular and non-cellular components,and it plays an important role in the development,proliferation,invasion,and progression of ICC and determines the heterogeneity and malignancy of ICC to a certain degree.This article reviews the cellular components(such as T cells,B cells,natural killer cells,dendritic cells,neutrophils,macrophages,myeloid-derived suppressor cells)and non-cellular components(such as chemokines and cytokines)within the ICC TSIME,as well as the complex mechanisms of interaction between these components,and it also reviews the spatial interactions between immune cells and tumor cells,in order to provide potential research directions for ICC immunotherapy and new ideas for the effective and precise treatment of ICC in the future.关键词
胆管上皮癌/肿瘤微环境/淋巴细胞Key words
Cholangiocarcinoma/Tumor Microenvironment/Lymphocytes引用本文复制引用
张秋露,李卓,刘从容,郭丽梅..肝内胆管癌间质-免疫微环境内成分及其相互作用[J].临床肝胆病杂志,2025,41(3):594-600,7.
