日用化学工业（中英文）2025，Vol.55Issue(3)：333-340,8.DOI:10.3969/j.issn.2097-2806.2025.03.009
黄芩与丹参配伍面膜剂的成型工艺及抗菌活性研究
Research on the forming process and antibacterial activity of the facial mask combined Scutellaria baicalensis Georgi with Salvia miltiorrhiza Bge.
摘要
Abstract
Acne is a common skin disease,and the occurrence of acne is closely related to Propionibacterium acnes.Research shows that Scutellaria baicalensis Georgi and Salvia miltiorrhiza Bge.have good antibacterial activities,especially to Propionibacterium acnes.The facial mask combined S.baicalensis Georgi with S.miltiorrhiza Bge.was prepared,and its forming process was optimized through response surface test.A rapid analysis technology for active ingredients was established using high performance liquid chromatography(HPLC),and the experiments were held to investigate the antibacterial activities of Propionibacterium acnes and Staphylococcus aureus in vitro.The results show that three main factors affecting the forming process are glycerol,1,3-butanediol and hydroxyethyl cellulose identified by single factor test.Box-Behnken test and response surface method are used to optimize the variation parameters of the three significant factors,and its optimal process conditions.The twelve indicative activities in the facial mask are identified by HPLC,and the rapid quality analysis method and its chromatographic conditions are established.Also,the bacteriostatic test in vitro of the facial mask confirms that it shows certain bacteriostatic effects on Propionibacterium acens and Staphylococcus aureus,and can exert effectively and continuously within ten hours.When it is combined with positive drug DP-300,it shows better synergistic or additive bacteriostatic effects,which are considered as the mild bacteriostatic effects due to facial mask.关键词
黄芩/丹参/面膜剂/痤疮/抗菌活性Key words
Scutellaria baicalensis Georgi/Salvia miltiorrhiza Bge./facial mask/acne/antibacterial activity分类
化学工程引用本文复制引用
宋卫强,陈亚莉,杨红艳,张帆..黄芩与丹参配伍面膜剂的成型工艺及抗菌活性研究[J].日用化学工业（中英文）,2025,55(3):333-340,8.基金项目
国家中医药管理局科技专项(GZY-KJS-2018-004) （GZY-KJS-2018-004）
南充市科技战略合作项目(20SXFWDF0004) （20SXFWDF0004）
