有色金属材料与工程2025，Vol.46Issue(1)：11-20,10.DOI:10.13258/j.cnki.nmme.20241224002
无机金属声敏剂在肿瘤声动力治疗中的应用现状
Applications status of inorganic metal sonosensitizers in sonodynamic therapy of tumors
摘要
Abstract
With the rapid development of nanomedicine technology,sonodynamic therapy(SDT),as an emerging non-invasive therapy method,has gradually become a research hotspot due to its ablility to effectively treat deep tumors while causing minimal damage to surrounding tissues.Sonosensitizer is an indispensable component in the SDT,as their structure and properties directly determine the efficacy of SDT.Compared with the traditional organic sonosensitizers,inorganic metal sonosensitizers offer advantages such as higher stability,controllable morphology and long circulation time in the human body,which greatly extend their research applications in SDT.The possible mechanisms of SDT were briefly investigated,i.e.,cavitation effect and generation of reactive oxygen species.The formulation designs,anti-tumor mechanisms and optimization strategies for treating tumors of inorganic metal sonosensitizers were summarized,and the current challenges and future development directions of SDT were discussed.It is expected to provide a reference for the future screening of inorganic metal sonosensitizers in SDT.关键词
声动力治疗/无机金属声敏剂/超声/活性氧Key words
sonodynamic therapy/inorganic metal sonosensitizers/ultrasound/reactive oxygen species引用本文复制引用
刘学雨,张豫龙,缪煜清,欧阳瑞镯..无机金属声敏剂在肿瘤声动力治疗中的应用现状[J].有色金属材料与工程,2025,46(1):11-20,10.基金项目
中国五矿集团有限公司科技专项计划资助项目(2022ZXA02) （2022ZXA02）
