有色金属材料与工程2025，Vol.46Issue(1)：29-38,10.DOI:10.13258/j.cnki.nmme.20240312004
基于两性离子聚合物的金属有机框架涂层的制备及抗菌性研究
Preparation and antibacterial properties of metal-organic framework coating based on zwitterionic polymers
摘要
Abstract
Titanium and its alloys are widely used in the biomedical field due to their excellent mechanical properties and biocompatibility.However,titanium and its alloys lack antibacterial capabilities.In order to enhance the antibacterial properties of titanium alloys,altering the surface structure and composition is an effective approach.Titanium dioxide nanotube(TN)on the surface of Ti6Al4V was prepared by anodization method,followed by grafting poly sulfobetaine methacrylate(PSBMA)onto TN surfaces.Zeolitic imidazolate framework-8(ZIF-8)loaded with ciprofloxacin(CIP)was synthesized on PSBMA-TN surfaces using a hydrothermal method to form a antibacterial coating of CIP@ZIF-8/PSBMA-TN(CZPT)with pH responsive properties.The performance of the coatings was evaluated through wettability tests and antibacterial tests.The results showed that the contact angle of Ti6Al4V with water was 71.50°,while the contact angle of CZPT with water was 14.20°,indicating significantly improved hydrophilicity.CZPT coating exhibited good antimicrobial properties with bacteriostatic rates of 96％and 65％against e.coli and staphylococcus aureus,respectively.关键词
医用钛合金/表面改性/两性离子聚合物/ZIF-8/抗菌涂层Key words
medical titanium alloy/surface modification/zwitterionic polymers/ZIF-8/antibacterial coating分类
金属材料引用本文复制引用
叶仁鹏,马凤仓,李伟,陈小红,刘新宽,张柯..基于两性离子聚合物的金属有机框架涂层的制备及抗菌性研究[J].有色金属材料与工程,2025,46(1):29-38,10.基金项目
国家自然科学基金资助项目(51771119) （51771119）
上海市自然科学基金资助项目(17ZR1419600) （17ZR1419600）
