生物信息学2025，Vol.23Issue(1)：28-39,12.DOI:10.12113/202309007
癌症精准治疗中的合成致死互作研究
Synthetic lethality in precision therapies for cancers
摘要
Abstract
At the forefront of contemporary anti-cancer research,precision therapy provides personalized treatment strategies by thoroughly mining the clinical pathology and molecular characteristics of cancer.Compared to conventional therapeutics,precision therapy significantly improves the success rate of cancer treatment.However,in clinical practice,precision therapy is still in its infancy,and efficiently designing personalized treatment plans for patients remains a challenge.Synthetic lethality,as a kind of genetic interaction,refers to the phenomenon that cell death occurs only when two specific genes are simultaneously inactivated,while individual inactivation of these genes has no significant impact on cell survival.Based on the principle of synthetic lethality,researchers can effectively integrate various omics data to predict drug efficacy,and to study drug repositioning and combination,all of which can provide effective treatment strategies for patients.Given the immense potential of synthetic lethality in precision therapy,in this review we comprehensively summarized data resources and methodologies pertaining to synthetic lethality,and deliberated upon both the applicability and the challenges of synthetic lethality in cancer precision therapy.We also discussed the insightful perspectives on this topic.关键词
合成致死/癌症/精准治疗/靶向治疗/药物药效Key words
Synthetic lethality/Cancer/Precision medicine/Targeted therapy/Drug response分类
药学引用本文复制引用
陈佳豪,黄玉娥,汪泉,姜伟..癌症精准治疗中的合成致死互作研究[J].生物信息学,2025,23(1):28-39,12.基金项目
国家自然科学基金面上项目(No.62172213,61872183). （No.62172213,61872183）
