生物信息学2025，Vol.23Issue(1)：50-60,11.DOI:10.12113/202306004
柯萨奇病毒A组6型VP1的主要特性及表位预测分析
Predictive analysis of main characteristics and epitopes of VP1 from Coxsackievirus A6
摘要
Abstract
To predict and analyze the main characteristics and epitopes of VP1 in the viral protein(VP)of Coxsackievirus A6(CV-A6)isolated from Xiangyang area using bioinformatics methods.The CV-A6 VP1's main characteristics including physicochemical properties,structural features,sequence characteristics,affinity and B/T cell epitopes are predicted and analyzed by software and online sites such as ProtParam,SOPMA,Phyre 2,DNAstar v8.1.3,Mega11,ABCpred,ElliPro,NetMHCpan-4.1,NetMHCIIpan-4.0.The isolate,VP1,is a basic,unstable,hydrophilic protein which has the secondary structure mainly consists of random coil,disparate nucleotide(amino acid)homology,12 amino acid mutation sites,and belongs to the D3a isoform.There are also multiple potential and dominant B/T cell epitopes for VP1.The CV-A6 Xiangyang isolate co-evolved and co-circulated with CV-A6 in Guangxi and Guangdong,China,and has certain immune potential,which can provide scientific basis and reference for molecular epidemiological surveillance and the development of multivalent vaccines.关键词
CV-A6/VP1/生物信息学/主要特性/表位Key words
CV-A6/VP1/Bioinformatics/Main characteristic/Epitope分类
基础医学引用本文复制引用
刘益文,张晓雯,高邦婷,项钦戈,张晨阳,左成,杨欢,汪大巍,张高博..柯萨奇病毒A组6型VP1的主要特性及表位预测分析[J].生物信息学,2025,23(1):50-60,11.基金项目
武汉华夏理工学院校级科研基金项目(No.22011). （No.22011）
