生殖医学杂志2025，Vol.34Issue(3)：291-297,7.DOI:10.3969/j.issn.1004-3845.2025.03.003
子宫动脉血流参数联合血清HLA-G、PTX-3对妊娠期高血压疾病孕妇妊娠结局的预测价值
The predictive value of uterine artery blood flow parameters combined with serum human leukocyte antigen-G and Pentraxin-3 levels for pregnancy outcomes among pregnant women with hypertensive disorder of pregnancy
摘要
Abstract
Objective:To investigate the predictive value of uterine artery blood flow parameters as well as serum levels of human leukocyte antigen-G(HLA-G)and pentraxin-3(PTX-3)for pregnancy outcomes in patients with hypertensive disorder of pregnancy(HDP). Methods:A total of 278 HDP patients admitted to Northern Theater Command General Hospital from March 2022 to March 2024 were recruited as the study subjects(HDP group),and 278 healthy pregnant women during the same period were selected as the control group.At the same time,the patients in the HDP group were categorized into the group with poor outcomes(61 cases)and the group with good outcomes(217 cases)according to the different pregnancy outcomes.Color Doppler ultrasound diagnostic equipment was used to detect the maximum systolic blood flow velocity(S)and diastolic blood flow velocity(D)of the uterine artery in patients,S/D,uterine artery resistance index(RI),and uterine artery pulsatility index(PI)was calculated.Enzyme linked immunosorbent assay(ELISA)was used to detect serum HLA-G and PTX-3 levels in subjects,and the general characteristics,uterine artery blood flow parameters,and serum HLA-G and PTX-3 levels were compared among HDP patients with different pregnancy outcomes.Multivariate logistic regression was used to analyze the influencing factors of adverse pregnancy outcomes in HDP patients,and the receiver operating characteristic(ROC)curve was used to analyze the predictive value of uterine artery blood flow parameters combined with serum HLA-G and PTX-3 for adverse pregnancy outcomes in HDP patients. Results:Serum HLA-G level was significantly lower and PTX-3 level was significantly higher in the HDP group than those in the control group(P＜0.05).S/D,RI,PI and serum PTX-3 level were significantly higher and serum HLA-G level was significantly lower in the poor outcome group than those in the good outcome group(P＜0.05).Logistic regression analysis showed that S/D,RI,PI,and serum HLA-G and PTX-3 levels were influential factors of adverse pregnancy outcomes in HDP patients(P＜0.05).The ROC results showed that the area under the curve(AUC)of uterine artery flow parameters combined with serum HLA-G and PTX-3 levels to predict adverse pregnancy outcomes in patients with HDP[0.976,95％CI(0.950,0.991)]was higher than those predicted by S/D(Z=4.550),RI(Z=5.617),PI(Z=4.799),HLA-G(Z=4.368)and PTX-3(Z=4.695)respectively(P＜0.001). Conclusions:Both uterine artery blood flow parameters and serum HLA-G and PTX-3 levels are correlated with pregnancy outcomes in HDP patients.The combination of blood flow parameters and serum HLA-G and PTX-3 levels has a good predictive effect on adverse pregnancy outcomes in HDP patients.关键词
子宫动脉/妊娠期高血压疾病/人类白细胞抗原-G/正五聚蛋白-3/预测价值Key words
Uterine artery/Hypertensive disorder of pregnancy/Human leukocyte antigen-G/Pentraxin-3/Predictive value分类
医药卫生引用本文复制引用
李芷舒,鲁海鸥,王英华,于月新..子宫动脉血流参数联合血清HLA-G、PTX-3对妊娠期高血压疾病孕妇妊娠结局的预测价值[J].生殖医学杂志,2025,34(3):291-297,7.基金项目
辽宁省自然科学基金指导计划项目(2019-ZD-1037) （2019-ZD-1037）
